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Team:Amsterdam/9 May 2011
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{{:Team:Amsterdam/Header}} | {{:Team:Amsterdam/Header}} | ||
{{:Team:Amsterdam/Notebook/Calendar}} | {{:Team:Amsterdam/Notebook/Calendar}} | ||
| - | = '''Meeting 9''' = | + | ='''09-05-2011 | Meeting 9'''= |
| - | '''Funding''' | + | =='''Funding'''== |
*NISB sponsored us! | *NISB sponsored us! | ||
| - | *Some | + | *Some companies rejected us (added to the Masterlist) |
=='''Projects discussion'''== | =='''Projects discussion'''== | ||
| - | '''Methane producing ''E.coli''''' | + | ==='''Methane producing ''E.coli'''''=== |
*Sequences of the genes were found | *Sequences of the genes were found | ||
*3 multi subunit proteins | *3 multi subunit proteins | ||
| Line 14: | Line 14: | ||
*Try to produce '''ethylene''' instead of methane | *Try to produce '''ethylene''' instead of methane | ||
| - | '''Ethylene producing ''E.coli''''' | + | ==='''Ethylene producing ''E.coli'''''=== |
*Only one enzyme is needed and a product in TCA cycle | *Only one enzyme is needed and a product in TCA cycle | ||
*3 2-oxoglutarate ⇒ 2 ethylene + succinate | *3 2-oxoglutarate ⇒ 2 ethylene + succinate | ||
| Line 20: | Line 20: | ||
*It can be edited to be more heat resistent | *It can be edited to be more heat resistent | ||
*Applications: | *Applications: | ||
| - | + | ===Attracting bacteria=== | |
| + | **Based on pheromones? | ||
**Use it in plants | **Use it in plants | ||
***A lot of responses in plants to ethylene | ***A lot of responses in plants to ethylene | ||
| Line 32: | Line 33: | ||
*Search for membrane proteins as targets | *Search for membrane proteins as targets | ||
| - | '''Hookworm''' | + | ===='''Hookworm'''==== |
*It secretes a PAMP | *It secretes a PAMP | ||
*Find a receptor that binds the PAMP | *Find a receptor that binds the PAMP | ||
| - | '''Other possible diseases''' | + | ===='''Other possible diseases'''==== |
*Chagas disease | *Chagas disease | ||
| - | '''What should be checked for each disease''' | + | ===='''What should be checked for each disease'''==== |
*Expense | *Expense | ||
*Diagnose time present | *Diagnose time present | ||
| Line 50: | Line 51: | ||
*Sample it can be detected in | *Sample it can be detected in | ||
| - | '''Opportunistic infections''' | + | ==='''Opportunistic infections'''=== |
*Leishmania spp | *Leishmania spp | ||
*Toxoplasma spp. | *Toxoplasma spp. | ||
Revision as of 12:50, 6 July 2011
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09-05-2011 | Meeting 9
Funding
- NISB sponsored us!
- Some companies rejected us (added to the Masterlist)
Projects discussion
Methane producing E.coli
- Sequences of the genes were found
- 3 multi subunit proteins
- One protein is membrane bound, this is a problem, because these proteins fold different in different membranes of organisms.
- How to check the methane production?
- Try to produce ethylene instead of methane
Ethylene producing E.coli
- Only one enzyme is needed and a product in TCA cycle
- 3 2-oxoglutarate ⇒ 2 ethylene + succinate
- Plasmid is already available
- It can be edited to be more heat resistent
- Applications:
Attracting bacteria
- Based on pheromones?
- Use it in plants
- A lot of responses in plants to ethylene
Neglected diseases
Kala-azar
- Parasite called Leishmania
- Cell necrosis in skin
- Present diagnostic is with antibodies
- Peanut agglutin is possible binding target
- Search for membrane proteins as targets
Hookworm
- It secretes a PAMP
- Find a receptor that binds the PAMP
Other possible diseases
- Chagas disease
What should be checked for each disease
- Expense
- Diagnose time present
- Diagnose time with new bac
- How quick is the disease infection/critical point
- Incubation time
- PAMP
- Receptor
- Life stage detection and life expectancy
- Sample it can be detected in
Opportunistic infections
- Leishmania spp
- Toxoplasma spp.
- Pneumocystis jiroveci
