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Team:Amsterdam/9 May 2011
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{{:Team:Amsterdam/Header}} | {{:Team:Amsterdam/Header}} | ||
{{:Team:Amsterdam/Notebook/Calendar}} | {{:Team:Amsterdam/Notebook/Calendar}} | ||
| - | = | + | =09-05-2011 | Meeting 9= |
| - | + | ==Funding== | |
| - | == | + | |
*NISB sponsored us! | *NISB sponsored us! | ||
*Some companies rejected us (added to the Masterlist) | *Some companies rejected us (added to the Masterlist) | ||
| - | == | + | ==Projects discussion== |
| - | === | + | ===Methane producing ''E.coli''=== |
*Sequences of the genes were found | *Sequences of the genes were found | ||
*3 multi subunit proteins | *3 multi subunit proteins | ||
| Line 13: | Line 12: | ||
*How to check the methane production? | *How to check the methane production? | ||
*Try to produce '''ethylene''' instead of methane | *Try to produce '''ethylene''' instead of methane | ||
| - | + | ===Ethylene producing ''E.coli''=== | |
| - | === | + | |
*Only one enzyme is needed and a product in TCA cycle | *Only one enzyme is needed and a product in TCA cycle | ||
*3 2-oxoglutarate ⇒ 2 ethylene + succinate | *3 2-oxoglutarate ⇒ 2 ethylene + succinate | ||
| Line 24: | Line 22: | ||
**Use it in plants | **Use it in plants | ||
***A lot of responses in plants to ethylene | ***A lot of responses in plants to ethylene | ||
| - | + | ===Neglected diseases=== | |
| - | === | + | ====Kala-azar==== |
| - | + | ||
*Parasite called ''Leishmania'' | *Parasite called ''Leishmania'' | ||
*Cell necrosis in skin | *Cell necrosis in skin | ||
| Line 32: | Line 29: | ||
*Peanut agglutin is possible binding target | *Peanut agglutin is possible binding target | ||
*Search for membrane proteins as targets | *Search for membrane proteins as targets | ||
| - | + | ====Hookworm==== | |
| - | ==== | + | |
*It secretes a PAMP | *It secretes a PAMP | ||
*Find a receptor that binds the PAMP | *Find a receptor that binds the PAMP | ||
| - | + | ====Other possible diseases==== | |
| - | ==== | + | |
*Chagas disease | *Chagas disease | ||
| - | + | ====What should be checked for each disease==== | |
| - | ==== | + | |
*Expense | *Expense | ||
*Diagnose time present | *Diagnose time present | ||
| Line 50: | Line 44: | ||
*Life stage detection and life expectancy | *Life stage detection and life expectancy | ||
*Sample it can be detected in | *Sample it can be detected in | ||
| - | + | ===Opportunistic infections=== | |
| - | === | + | *''Leishmania spp.'' |
| - | *Leishmania spp | + | *''Toxoplasma spp.'' |
| - | *Toxoplasma spp. | + | *''Pneumocystis jiroveci'' |
| - | *Pneumocystis jiroveci | + | |
| - | + | ||
{{:Team:Amsterdam/Footer}} | {{:Team:Amsterdam/Footer}} | ||
Latest revision as of 10:26, 21 September 2011
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09-05-2011 | Meeting 9
Funding
- NISB sponsored us!
- Some companies rejected us (added to the Masterlist)
Projects discussion
Methane producing E.coli
- Sequences of the genes were found
- 3 multi subunit proteins
- One protein is membrane bound, this is a problem, because these proteins fold different in different membranes of organisms.
- How to check the methane production?
- Try to produce ethylene instead of methane
Ethylene producing E.coli
- Only one enzyme is needed and a product in TCA cycle
- 3 2-oxoglutarate ⇒ 2 ethylene + succinate
- Plasmid is already available
- It can be edited to be more heat resistent
- Applications:
Attracting bacteria
- Based on pheromones?
- Use it in plants
- A lot of responses in plants to ethylene
Neglected diseases
Kala-azar
- Parasite called Leishmania
- Cell necrosis in skin
- Present diagnostic is with antibodies
- Peanut agglutin is possible binding target
- Search for membrane proteins as targets
Hookworm
- It secretes a PAMP
- Find a receptor that binds the PAMP
Other possible diseases
- Chagas disease
What should be checked for each disease
- Expense
- Diagnose time present
- Diagnose time with new bac
- How quick is the disease infection/critical point
- Incubation time
- PAMP
- Receptor
- Life stage detection and life expectancy
- Sample it can be detected in
Opportunistic infections
- Leishmania spp.
- Toxoplasma spp.
- Pneumocystis jiroveci
