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Team:Amsterdam/12 May 2011
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(Created page with "{{:Team:Amsterdam/Header}} = '''UvA Meeting for topics discussion''' = ==='''Neglected disease'''=== '''Kala-azar''' *Protein is unstable if it is secreted *This is difficult to...") |
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{{:Team:Amsterdam/Header}} | {{:Team:Amsterdam/Header}} | ||
| - | = | + | {{:Team:Amsterdam/Notebook/Calendar}} |
| + | =12-05-11 | UvA Meeting for topics discussion= | ||
| - | == | + | ==Neglected disease== |
| - | + | ===Kala-azar=== | |
*Protein is unstable if it is secreted | *Protein is unstable if it is secreted | ||
*This is difficult to use in ''E. coli'' | *This is difficult to use in ''E. coli'' | ||
| Line 13: | Line 14: | ||
**This will be checked | **This will be checked | ||
| - | + | ===Hookworm=== | |
*Detectable in human blood | *Detectable in human blood | ||
*GP63 protein is expressed in multiple diseases | *GP63 protein is expressed in multiple diseases | ||
*This can't be the target protein | *This can't be the target protein | ||
| - | + | ===Buruli ulcer=== | |
*Is mycolactone specific for this disease? | *Is mycolactone specific for this disease? | ||
*When ARP is present, mycolactone is inactive | *When ARP is present, mycolactone is inactive | ||
| Line 24: | Line 25: | ||
*Can we order mycolactone? | *Can we order mycolactone? | ||
| - | + | ==Target the host not the disease!== | |
*We will look into this | *We will look into this | ||
*Attract the parasite with a pheromone | *Attract the parasite with a pheromone | ||
| - | + | ==Ethylene producing ''E.coli''== | |
*Evolution takes to long for iGEM | *Evolution takes to long for iGEM | ||
**It doesn't produce biobricks | **It doesn't produce biobricks | ||
*Some literature about the topic will be sent to us | *Some literature about the topic will be sent to us | ||
{{:Team:Amsterdam/Footer}} | {{:Team:Amsterdam/Footer}} | ||
Latest revision as of 10:26, 21 September 2011
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12-05-11 | UvA Meeting for topics discussion
Neglected disease
Kala-azar
- Protein is unstable if it is secreted
- This is difficult to use in E. coli
- A heat test can be used, but will not yield any biobricks
- Peanut agluttin binds to LPG
- This LPG can be found in multiple organisms
- This will lead to false positives
- This LPG can be found in multiple organisms
- Are there antibodies against the promastigotes/amastigotes?
- This will be checked
Hookworm
- Detectable in human blood
- GP63 protein is expressed in multiple diseases
- This can't be the target protein
Buruli ulcer
- Is mycolactone specific for this disease?
- When ARP is present, mycolactone is inactive
- Use the receptor that M. ulcerans binds to and place it onto an E. coli
- Can we order mycolactone?
Target the host not the disease!
- We will look into this
- Attract the parasite with a pheromone
Ethylene producing E.coli
- Evolution takes to long for iGEM
- It doesn't produce biobricks
- Some literature about the topic will be sent to us
