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Team:Amsterdam/9 May 2011
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'''Funding''' | '''Funding''' | ||
| - | *NISB sponsored | + | *NISB sponsored us! |
*Some rejections were made | *Some rejections were made | ||
=='''Projects discussion'''== | =='''Projects discussion'''== | ||
Revision as of 12:54, 24 June 2011
Meeting 9
Funding
- NISB sponsored us!
- Some rejections were made
Projects discussion
Methane producing E.coli
- Sequences of the genes were found
- 3 multi subunit proteins
- One protein is membrane bound, this is a problem, because these proteins fold different in different membranes of organisms.
- How to check the methane production?
⇒ Try to produce ethylene instead of methane
Ethylene producing E.coli
- Only one enzyme is needed and a product in TCA cycle
- 3 2-oxoglutarate ⇒ 2 ethylene + succinate
- Plasmid is already available
- It can be edited to be more heat resistent
- Applications:
- Bacteria attraction (extra receptor)
- Use it in plants
- A lot of responses in plants to ethylene
Neglected disease
Kala-azar
- Parasite called Leishmania
- Cell necrosis in skin
- Present diagnostic is with antibodies
- Peanut agglutin is possible binding target
- Search for membrane proteins as targets
Hookworm
- It secretes a PAMP
- Find a receptor that binds the PAMP
Other possible diseases
- Chagas disease
What should be checeked for each disease
- Expense
- Diagnose time present
- Diagnose time with new bac
- How quick is the disease infection/critical point
- Incubation time
- PAMP
- Receptor
- Life stage detection and life expectancy
- Sample it can be detected
Opportunistic infections
- Leishmania spp
- Toxoplasma spp.
- Pneumocystis jiroveci
