Revision as of 10:11, 27 June 2011 by Jorickm (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

• Home
• Team
  • Students
  • Advisors
  • Lab Environment
• Project
  • Description
  • Modules
  • Data Page
  • Safety
  • Applications
  • Attributions
  • Acknowledgements
• BioBricks
  • Overview
  • Basic Parts
  • Composite Parts
• Labwork
  • Notebook
  • Protocols
  • Characterization
  • Data Analysis
• Human Outreach
  • Collaboration
  • Education
  • Media
• Sponsors
  • Companies
  • Help Us

UvA Meeting for topics discussion

Neglected disease

Kala-azar

• Protein is unstable if it is secreted
• This is difficult to use in E. coli
• A heat test can be used, but will not yield any biobricks
• Peanut agluttin binds to LPG
  • This LPG can be found in multiple organisms
    • This will lead to false positives
• Are there antibodies against the promastigotes/amastigotes?
  • This will be checked

Hookworm

• Detectable in human blood
• GP63 protein is expressed in multiple diseases
• This can't be the target protein

Buruli ulcer

• Is mycolactone specific for this disease?
• When ARP is present, mycolactone is inactive
• Use the receptor that M. ulcerans binds to and place it onto an E. coli
• Can we order mycolactone?

Target the host not the disease!

• We will look into this
• Attract the parasite with a pheromone

Ethylene producing E.coli

• Evolution takes to long for iGEM
  • It doesn't produce biobricks
• Some literature about the topic will be sent to us