"
Team:Amsterdam/12 May 2011
From 2011.igem.org
(Difference between revisions)
Jorickm (Talk | contribs)
(Created page with "{{:Team:Amsterdam/Header}} = '''UvA Meeting for topics discussion''' = ==='''Neglected disease'''=== '''Kala-azar''' *Protein is unstable if it is secreted *This is difficult to...")
Newer edit →
(Created page with "{{:Team:Amsterdam/Header}} = '''UvA Meeting for topics discussion''' = ==='''Neglected disease'''=== '''Kala-azar''' *Protein is unstable if it is secreted *This is difficult to...")
Newer edit →
Revision as of 10:11, 27 June 2011
UvA Meeting for topics discussion
Neglected disease
Kala-azar
- Protein is unstable if it is secreted
- This is difficult to use in E. coli
- A heat test can be used, but will not yield any biobricks
- Peanut agluttin binds to LPG
- This LPG can be found in multiple organisms
- This will lead to false positives
- This LPG can be found in multiple organisms
- Are there antibodies against the promastigotes/amastigotes?
- This will be checked
Hookworm
- Detectable in human blood
- GP63 protein is expressed in multiple diseases
- This can't be the target protein
Buruli ulcer
- Is mycolactone specific for this disease?
- When ARP is present, mycolactone is inactive
- Use the receptor that M. ulcerans binds to and place it onto an E. coli
- Can we order mycolactone?
Target the host not the disease!
- We will look into this
- Attract the parasite with a pheromone
Ethylene producing E.coli
- Evolution takes to long for iGEM
- It doesn't produce biobricks
- Some literature about the topic will be sent to us
