Team:SJTU-BioX-Shanghai

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<div id="title"><b>The Project: Condon Switch Controlling Protein Biosynthesis</b></div>
<div id="title"><b>The Project: Condon Switch Controlling Protein Biosynthesis</b></div>
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<p>SJTU-BioX-Shanghai iGEM team is designing a modulating device that achieves fine tuning of target protein biosynthesis (translation). </p>
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<p>SJTU-BioX-Shanghai iGEM team is designing a set of Codon-Switches that regulate target protein biosynthesis (translation).</p>
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<p>In our Rare-Codon Switch, the translation of the protein can be finely turned up/down with the control of the number of rare codons (Reporter) and the different strength of tRNA induction (Modulator).</p>
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<p>The translation of the protein can be finely turned up/down with the control of the number of rare codons <b>(Reporter)</b> and the different strength of tRNA induction <b>(Modulator)</b>.</p>
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<p>Besides, our device can be made into switches that can be turned on/off without background noise in two ways. One is to use stop codon as the controlling element, the Stop-Codon Switch. The other is to use any codon but the original start codon to initiate translation, the Initial-Codon Switch.</p>
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<p>Besides, our device can be made into a real switch that can be turned on/off without background protein expression in two ways. One is to use any codon but initial codon to initiate translation, the other is to use stop codon as the controlling element.  
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<img src="/wiki/images/e/e2/11SJTU_home_fig1.jpg"  alt="Project" style="float:right;"/></p>
<img src="/wiki/images/e/e2/11SJTU_home_fig1.jpg"  alt="Project" style="float:right;"/></p>
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<p>Moreover, our design would be a brand-new way to selectively express part of a gene or introduce point mutations into target residues in proteins, thus favoring the study of the important domains or residues of a target protein.  
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<p>Our design has expanded the regulating tools for synthetic biology, introduced a brand-new way to incorporate point mutation into protein and study the important domains of a protein. See more about project applications, click <a href="/Team:SJTU-BioX-Shanghai/Application">here</a>.</p>
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<a href="/wiki/Team:SJTU-BioX-Shanghai/Project">>>Goto Project</a>
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Revision as of 03:58, 5 October 2011

    •
    The Project: Condon Switch Controlling Protein Biosynthesis

    SJTU-BioX-Shanghai iGEM team is designing a set of Codon-Switches that regulate target protein biosynthesis (translation).

    In our Rare-Codon Switch, the translation of the protein can be finely turned up/down with the control of the number of rare codons (Reporter) and the different strength of tRNA induction (Modulator).

    Besides, our device can be made into switches that can be turned on/off without background noise in two ways. One is to use stop codon as the controlling element, the Stop-Codon Switch. The other is to use any codon but the original start codon to initiate translation, the Initial-Codon Switch.

    Project

    Our design has expanded the regulating tools for synthetic biology, introduced a brand-new way to incorporate point mutation into protein and study the important domains of a protein. See more about project applications, click here.

    Team
    Parts
    Human practice

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