Team:SJTU-BioX-Shanghai

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<div class="title"><b>The Project: Condon Switch Controlling Protein Biosynthesis</b></div>
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<p>SJTU-BioX-Shanghai iGEM team is designing a modulating device that achieves fine tuning of target protein biosynthesis (translation). </p>
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<p>The translation of the protein can be finely turned up/down with the control of the number of rare codons and the different strength of tRNA induction.</p>
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<p>Besides, our device can be made into a real switch that can be turned on/off without background protein expression in two ways. One is to use any codon but initial codons to initiate translation, the other is to use stop codon as the controlling element.
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<p>Moreover, our design would be a brand-new way to selectively express part of a gene or introduce point mutations into target residues in proteins, thus favoring the study of the important domains or residues of a target protein.
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<a href="/wiki/Team:SJTU-BioX-Shanghai/Project">>>Goto Project</a>
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<div class="box"><div class="t"><b>Team</b></div></div>
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<div class="box"><div class="t"><b>Parts</b></div></div>
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    <div><li>Project Description</li>
 
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    <h2>A Synthetic-Biological System Controlling Translation Process</h2>
 
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    <p>2011 SJTU-BioX iGEM team is designing a system in which we will be able to control the expression of the target gene on the level of translation. Our system has provided a brand-new approach that can be universally applied to any protein expression system. In our system we can strictly switch on/off the translation of the target gene; we can selectively translate a part of the whole open reading frame; we can also shift certain amino acid residues to any of the 20 possible alternatives without altering the sequence of the gene. Our significant design offers a multi-purpose and universal way to regulate gene expression on translation level, to selectively express part of a gene, to introduce mutation to the target position of a protein and to study the important residues or domains of the target protein.</p>   
 
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<div class="cell"><li>TEAM</li></div>
 
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<div class="cell"><li>PARTS</li></div>
 
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<div class="cell"><li>MODELING</li></div>
 
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<div class="cell"><li>NOTEBOOK</li></div>
 
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<div class="cell"><li>SAFETY</li></div>
 
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<div class="cell"><li>HUMAN PRACTICE</li></div>
 
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<div class="cell"><li>ACKNOWLEDGEMENTS</li></div>
 
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<div class="cell"><li>SPONSORS</li></div>
 
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Revision as of 15:34, 3 October 2011

    •
    The Project: Condon Switch Controlling Protein Biosynthesis

    SJTU-BioX-Shanghai iGEM team is designing a modulating device that achieves fine tuning of target protein biosynthesis (translation).

    The translation of the protein can be finely turned up/down with the control of the number of rare codons and the different strength of tRNA induction.

    Besides, our device can be made into a real switch that can be turned on/off without background protein expression in two ways. One is to use any codon but initial codons to initiate translation, the other is to use stop codon as the controlling element. Project

    Moreover, our design would be a brand-new way to selectively express part of a gene or introduce point mutations into target residues in proteins, thus favoring the study of the important domains or residues of a target protein.

    >>Goto Project
    Team
    Parts
    Notebook
    Human Practice

    Retrieved from "http://2011.igem.org/Team:SJTU-BioX-Shanghai"