Team:SouthBend-Mishawaka-HS-2/Attributions

From 2011.igem.org

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Each team must clearly attribute work done by the team on this page.  They must distinguish work done by the team from work done by others, including the host labs, advisors, instructors, graduate students, and postgraduate masters students.
Each team must clearly attribute work done by the team on this page.  They must distinguish work done by the team from work done by others, including the host labs, advisors, instructors, graduate students, and postgraduate masters students.
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{{:Team:Heidelberg/Double}}
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{{:Team:Heidelberg/NivoSlider}}
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============================================================================================
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*** PLEASE NOTE: ***
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The contents and design of this wiki are published under the GNU Free Documentation License. You are granted the right to copy and modify our work, but you must publish your work under the same type of license while recognizing us the authors.
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Stefan Kleinsorg, Thomas Uhlig
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============================================================================================
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{{:Team:Heidelberg/Pagetop|home}}
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<div id="wrapperheadline">iGEM Heidelberg Mission 2010: miBricks</div><br>
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<div id="projectabstract">The great potential of gene therapy is currently limited by two major challenges:  tissue specific gene delivery and regulation of gene expression, either dependent on cell-specific properties or intentionally independent of the cellular context. We followed two synergistic tracks to address these problems.<br>
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One, we have developed a novel method for miRNA based gene expression tuning in mammalian cells, allowing the fine-tuning of gene expression based on synthetic miRNAs, as well as the cell specific on- and off-targeting based on endogenous miRNAs. We show that this method is functional in vivo and in vitro and prove the high potential of all three miRNA-based regulation approaches.<br>
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Two, we have developed a standardized and fast approach towards the creation of AAV-based gene delivery vectors. We have achieved exceptionally selective tissue-specific targeting <i>in vitro</i> and <i>in vivo</i> with hepatocyte specific delivery vectors.<br>
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We are happy to provide the synthetic biology community with two high impact innovations which will fuel the improvement of tissue specific gene therapy approaches and other medical applications of synthetic biology.</div><br><br>
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<div id="slider">
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<a href="https://2010.igem.org/Team:Heidelberg/Project/Capsid_Shuffling"><img src="https://static.igem.org/mediawiki/2010/e/ed/Slide_CapShuffling.png" alt="" rel="https://static.igem.org/mediawiki/2010/3/30/Slide_CapShuffling_thumb.png"/></a>
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<a href="https://2010.igem.org/Team:Heidelberg/Project/miMeasure"><img src="https://static.igem.org/mediawiki/2010/e/ee/Slide_miMeasure.png" alt="" rel="https://static.igem.org/mediawiki/2010/f/f0/Slide_miMeasure_thumb.png"/></a>
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<a href="https://2010.igem.org/Team:Heidelberg/Project/Mouse_Infection"><img src="https://static.igem.org/mediawiki/2010/7/72/Slider_in_vivo.png" alt="" rel="https://static.igem.org/mediawiki/2010/a/a3/Slider_in_vivo_thumb.png"/></a>
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</div><br><br><br><br><br><br>
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<div id="pics">
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<a class="piclinks" href="javascript:writeText('And we are not talking about fashion! In our team, a group of students was in charge of the computational interpretation and modeling of the data generated. Want to read more? Click <a href=&quot;https://2010.igem.org/Team:Heidelberg/Modeling&quot;>here</a>!')" onMouseOver="mouseOver(1)"  onMouseOut="mouseOut(1)" onMouseDown="mouseDown(1)" onMouseUp="mouseUp(1)">
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<img id="pic1" border=0 src="https://static.igem.org/mediawiki/2010/2/2d/Modeling_none.png" />
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</a>
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<a class="piclinks" href="javascript:writeText('Our team comprised a group of twenty motivated students from eight different countries, two instructors and eight advisors. Want to meet them? Click <a href=&quot;https://2010.igem.org/Team:Heidelberg/Team&quot;>here</a>!')" onMouseOver="mouseOver(2)" onMouseOut="mouseOut(2)" onMouseDown="mouseDown(2)" onMouseUp="mouseUp(2)">
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<img id="pic2"  border=0 src="https://static.igem.org/mediawiki/2010/8/82/Team_none.png"; />
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</a>
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<a class="piclinks" href="javascript:writeText('A philosophy and a psychology student helped us to understand how Synthetic Biology interacts with society. Click <a href=&quot;https://2010.igem.org/Team:Heidelberg/Human_Practices&quot;>here</a> to see how our science is percieved by the public!')" onMouseOver="mouseOver(3)" onMouseOut="mouseOut(3)" onMouseDown="mouseDown(3)" onMouseUp="mouseUp(3)">
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<img id="pic3"  border=0 src="https://static.igem.org/mediawiki/2010/a/a7/Human_practices_none.png" />
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</a>
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<center><table id="desc-table"><tr><td><div id ="desc" border=0><center>Please click a Button to get more information! </center></div></td></tr></table></center>
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<a class="piclinks" href="javascript:writeText('As in any piece of research, we have been keeping detailed notebooks with the experiments we have done. Want to retrace our steps? Click <a href=&quot;https://2010.igem.org/Team:Heidelberg/Notebook&quot;>here</a>!')" onMouseOver="mouseOver(4)" onMouseOut="mouseOut(4)" onMouseDown="mouseDown(4)" onMouseUp="mouseUp(4)">
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<img  id="pic4" border=0 src="https://static.igem.org/mediawiki/2010/8/8f/Notebook_none.png" />
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</a>
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<a class="piclinks" href="javascript:writeText('We have generated more than 100 parts that have been sent to iGEM headquarters. Want to know which ones? Click <a href=&quot;https://2010.igem.org/Team:Heidelberg/Parts&quot;>here</a>!')" onMouseOver="mouseOver(5)" onMouseOut="mouseOut(5)" onMouseDown="mouseDown(5)" onMouseUp="mouseUp(5)">
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<img id="pic5"  border=0 src="https://static.igem.org/mediawiki/2010/5/57/Parts_none.png" />
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</a>
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<a class="piclinks" href="javascript:writeText('Our team was sponsored by a non-profit organization, nine companies and three academic sponsors. Want to meet them? Click <a href=&quot;https://2010.igem.org/Team:Heidelberg/Support&quot;>here</a>!')" onMouseOver="mouseOver(6)" onMouseOut="mouseOut(6)" onMouseDown="mouseDown(6)" onMouseUp="mouseUp(6)">
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<img id="pic6"  border=0 src="https://static.igem.org/mediawiki/2010/4/46/Support_none.png" />
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</a>
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</div><br><br>
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<div class="clear"></div>
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</div>
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</html>
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{{:Team:Heidelberg/Pagemiddle}}
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<html>
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<body>
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<img src="https://static.igem.org/mediawiki/2010/a/a4/Igemhd2010_2s.png" width=268px/><br>
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<object type="application/x-shockwave-flash" data="http://www.oneplusyou.com/bb/files/countdown/countdown.swf?co=F09600&bgcolor=f2f2f2&date_month=11&date_day=05&date_year=0&un=IGEM JAMBOREE 2010&size=normal&mo=11&da=05&yr=2010" width="250" height="80"><param name="movie" value="http://www.oneplusyou.com/bb/files/countdown/countdown.swf?co=F09600&date_month=11&date_day=05&date_year=0&un=UNTIL IGEM JAMBOREE 2010&size=normal&mo=11&da=05&yr=2010" /><param name="bgcolor" value="#f2f2f2" /></object>
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<h3>The iGEM idea</h3>
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  </body>
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</html>
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{{:Team:Heidelberg/Bottom}}

Revision as of 20:01, 2 June 2011

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Attributions & Contributions

Each team must clearly attribute work done by the team on this page. They must distinguish work done by the team from work done by others, including the host labs, advisors, instructors, graduate students, and postgraduate masters students. Team:Heidelberg/Double Team:Heidelberg/NivoSlider Team:Heidelberg/Pagetop

iGEM Heidelberg Mission 2010: miBricks

The great potential of gene therapy is currently limited by two major challenges: tissue specific gene delivery and regulation of gene expression, either dependent on cell-specific properties or intentionally independent of the cellular context. We followed two synergistic tracks to address these problems.
One, we have developed a novel method for miRNA based gene expression tuning in mammalian cells, allowing the fine-tuning of gene expression based on synthetic miRNAs, as well as the cell specific on- and off-targeting based on endogenous miRNAs. We show that this method is functional in vivo and in vitro and prove the high potential of all three miRNA-based regulation approaches.
Two, we have developed a standardized and fast approach towards the creation of AAV-based gene delivery vectors. We have achieved exceptionally selective tissue-specific targeting in vitro and in vivo with hepatocyte specific delivery vectors.
We are happy to provide the synthetic biology community with two high impact innovations which will fuel the improvement of tissue specific gene therapy approaches and other medical applications of synthetic biology.








Please click a Button to get more information!


Team:Heidelberg/Pagemiddle

The iGEM idea

Team:Heidelberg/Bottom

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