Team:SouthBend-Mishawaka-HS-2/Attributions

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==Attributions & Contributions==
==Attributions & Contributions==
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Our team is very thankful for all the contributions made. Thanks to Professor Twaddle and Mr. Madden for guiding and providing knowledge. Thanks to the 2009 Gronigen Team for our promoter K190015 Designed by Michael Verhoeven. Thanks to the 2006 MIT team for the Wintergreen reporter J45119 Designed by Boyuan Zhu. Thanks to the Endy Lab for the GFP reporter E0840 Designed by Jennifer Braff.
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Each team must clearly attribute work done by the team on this page. They must distinguish work done by the team from work done by others, including the host labs, advisors, instructors, graduate students, and postgraduate masters students.
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We would like to thank all our sponsors listed below including the Lilly foundation for their generous grant and Ivy Tech for letting us use their lab.
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The contents and design of this wiki are published under the GNU Free Documentation License. You are granted the right to copy and modify our work, but you must publish your work under the same type of license while recognizing us the authors.
 
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<div id="wrapperheadline">iGEM Heidelberg Mission 2010: miBricks</div><br>
 
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<div id="projectabstract">The great potential of gene therapy is currently limited by two major challenges:  tissue specific gene delivery and regulation of gene expression, either dependent on cell-specific properties or intentionally independent of the cellular context. We followed two synergistic tracks to address these problems.<br>
 
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One, we have developed a novel method for miRNA based gene expression tuning in mammalian cells, allowing the fine-tuning of gene expression based on synthetic miRNAs, as well as the cell specific on- and off-targeting based on endogenous miRNAs. We show that this method is functional in vivo and in vitro and prove the high potential of all three miRNA-based regulation approaches.<br>
 
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Two, we have developed a standardized and fast approach towards the creation of AAV-based gene delivery vectors. We have achieved exceptionally selective tissue-specific targeting <i>in vitro</i> and <i>in vivo</i> with hepatocyte specific delivery vectors.<br>
 
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We are happy to provide the synthetic biology community with two high impact innovations which will fuel the improvement of tissue specific gene therapy approaches and other medical applications of synthetic biology.</div><br><br>
 
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<a class="piclinks" href="javascript:writeText('And we are not talking about fashion! In our team, a group of students was in charge of the computational interpretation and modeling of the data generated. Want to read more? Click <a href=&quot;https://2010.igem.org/Team:Heidelberg/Modeling&quot;>here</a>!')" onMouseOver="mouseOver(1)"  onMouseOut="mouseOut(1)" onMouseDown="mouseDown(1)" onMouseUp="mouseUp(1)">
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<a class="piclinks" href="javascript:writeText('And we are not talking about fashion! In our team, a group of students was in charge of the computational interpretation and modeling of the data generated. Want to read more? Click <a href=&quot;https://2011.igem.org/Team:SouthBend-Mishawaka-HS-2/Modeling&quot;>here</a>!')" onMouseOver="mouseOver(1)"  onMouseOut="mouseOut(1)" onMouseDown="mouseDown(1)" onMouseUp="mouseUp(1)">
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<a class="piclinks" href="javascript:writeText('Our team comprised a group of twenty motivated students from eight different countries, two instructors and eight advisors. Want to meet them? Click <a href=&quot;https://2010.igem.org/Team:Heidelberg/Team&quot;>here</a>!')" onMouseOver="mouseOver(2)" onMouseOut="mouseOut(2)" onMouseDown="mouseDown(2)" onMouseUp="mouseUp(2)">
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<a class="piclinks" href="javascript:writeText('Our team comprised a group of seven motivated students and four advisors. Want to meet them? Click <a href=&quot;https://2011.igem.org/Team:SouthBend-Mishawaka-HS-2/Team&quot;>here</a>!')" onMouseOver="mouseOver(2)" onMouseOut="mouseOut(2)" onMouseDown="mouseDown(2)" onMouseUp="mouseUp(2)">
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<a class="piclinks" href="javascript:writeText('As in any piece of research, we have been keeping detailed notebooks with the experiments we have done. Want to retrace our steps? Click <a href=&quot;https://2010.igem.org/Team:Heidelberg/Notebook&quot;>here</a>!')" onMouseOver="mouseOver(4)" onMouseOut="mouseOut(4)" onMouseDown="mouseDown(4)" onMouseUp="mouseUp(4)">
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<a class="piclinks" href="javascript:writeText('As in any piece of research, we have been keeping detailed notebooks with the experiments we have done. Want to retrace our steps? Click <a href=&quot;https://2011.igem.org/Team:SouthBend-Mishawaka-HS-2/Notebook&quot;>here</a>!')" onMouseOver="mouseOver(4)" onMouseOut="mouseOut(4)" onMouseDown="mouseDown(4)" onMouseUp="mouseUp(4)">
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<a class="piclinks" href="javascript:writeText('We have generated more than 100 parts that have been sent to iGEM headquarters. Want to know which ones? Click <a href=&quot;https://2010.igem.org/Team:Heidelberg/Parts&quot;>here</a>!')" onMouseOver="mouseOver(5)" onMouseOut="mouseOut(5)" onMouseDown="mouseDown(5)" onMouseUp="mouseUp(5)">
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<a class="piclinks" href="javascript:writeText('we used multiple parts in our device. Want to know which ones? Click <a href=&quot;https://2011.igem.org/Team:SouthBend-Mishawaka-HS-2/Parts&quot;>here</a>!')" onMouseOver="mouseOver(5)" onMouseOut="mouseOut(5)" onMouseDown="mouseDown(5)" onMouseUp="mouseUp(5)">
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<a class="piclinks" href="javascript:writeText('Our team was sponsored by a non-profit organization, nine companies and three academic sponsors. Want to meet them? Click <a href=&quot;https://2010.igem.org/Team:Heidelberg/Support&quot;>here</a>!')" onMouseOver="mouseOver(6)" onMouseOut="mouseOut(6)" onMouseDown="mouseDown(6)" onMouseUp="mouseUp(6)">
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<a class="piclinks" href="javascript:writeText('Igem is sponsored by 8 different groups. Want to find out more? Click <a href=&quot;https://2011.igem.org/Sponsors&quot;>here</a>!')" onMouseOver="mouseOver(6)" onMouseOut="mouseOut(6)" onMouseDown="mouseDown(6)" onMouseUp="mouseUp(6)">
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Latest revision as of 17:09, 24 June 2011

SouthBend-Mishawaka-HS-2 logo.png



Home Team Official Team Profile Project Parts Submitted to the Registry Modeling Notebook Safety Attributions


Attributions & Contributions

Our team is very thankful for all the contributions made. Thanks to Professor Twaddle and Mr. Madden for guiding and providing knowledge. Thanks to the 2009 Gronigen Team for our promoter K190015 Designed by Michael Verhoeven. Thanks to the 2006 MIT team for the Wintergreen reporter J45119 Designed by Boyuan Zhu. Thanks to the Endy Lab for the GFP reporter E0840 Designed by Jennifer Braff.
We would like to thank all our sponsors listed below including the Lilly foundation for their generous grant and Ivy Tech for letting us use their lab.
lilly_foundation_logo.gif http://www.iupui.edu/~ivy/_Assets/ivy_tech_logo.jpg Agilent-2c_Corp_Sig_50mm.jpg Alberta_innovates_30h.jpg ADSK_logo_S_black_web_32h.png EMDtwitterlogo.jpg Emergence_logo_30h.jpg Fbi_seal_mod_50px.png Geneart_Logo_Colour_h26px.png GinkgoBioworksLogo20px.png Mathworks_Logo_R1_RGB_26h.jpg Mit_logo_h26px.jpg Nasa_logo_h50px.png Nsf_logo_h26px.jpg Osli_official_logo_26h.png SynBERC_logo_h26px.png

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