Team:UNIPV-Pavia/Pavia

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<h2 class="art-postheader">Pavia</h2>
<h2 class="art-postheader">Pavia</h2>
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      <td><div align="justify"> One of the pivotal objectives of synthetic biology is to build complex gene networks with a predictable behavior by combining well-characterized basic modules.
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    <td height="567"><div id="l_pavia"> One of the pivotal objectives of synthetic biology is to build complex gene networks with a predictable behavior by combining well-characterized basic modules.
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As a proof of concept of this fundamental, our project aims at designing and implementing in E. coli a quorum sensing-based control system, able to regulate the concentration of a signaling molecule (3OC6-HSL) via a negative feedback loop.
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        As a proof of concept of this fundamental, our project aims at designing and implementing in E. coli a quorum sensing-based control system, able to regulate the concentration of a signaling molecule (3OC6-HSL) via a negative feedback loop.
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In order to obtain the desired output, fine-tuning of the circuit is necessary; therefore, a mathematical model of the control system will be derived and identified by data coming from ad hoc experiments performed on basic modules. Model simulations will be used to meet the design specifications of the biological controller, demonstrating that full characterization of basic parts is a major goal to predict the behavior of more complex circuits.</div></td>
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        In order to obtain the desired output, fine-tuning of the circuit is necessary; therefore, a mathematical model of the control system will be derived and identified by data coming from ad hoc experiments performed on basic modules. Model simulations will be used to meet the design specifications of the biological controller, demonstrating that full characterization of basic parts is a major goal to predict the behavior of more complex circuits.</div></td>
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      <img src="https://static.igem.org/mediawiki/2011/e/e5/UNIPV_Pavia1.jpg" title="University of Pavia: arcade" alt="" />
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      <img src="https://static.igem.org/mediawiki/2011/5/50/UNIPV_Pavia3.jpg" title="University of Pavia: statue of Alessandro Volta" alt="" />
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      <img src="https://static.igem.org/mediawiki/2011/6/69/UNIPV_Pavia5.jpg" title="University of Pavia: cenotaph for Ugo Foscolo" alt="" />
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      <img src="https://static.igem.org/mediawiki/2011/4/47/UNIPV_Pavia8.jpg" title="University of Pavia: the magnolia courtyard" alt="" /> <img src="https://static.igem.org/mediawiki/2011/e/e9/UNIPV_Pavia9.jpg" title="The cathedral" alt="" />
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      <div id="nivoslider-125-caption-0" class="nivo-html-caption">You can add captions too&#8230;</div>
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Revision as of 06:39, 10 September 2011

UNIPV TEAM 2011

Pavia

One of the pivotal objectives of synthetic biology is to build complex gene networks with a predictable behavior by combining well-characterized basic modules. As a proof of concept of this fundamental, our project aims at designing and implementing in E. coli a quorum sensing-based control system, able to regulate the concentration of a signaling molecule (3OC6-HSL) via a negative feedback loop. In order to obtain the desired output, fine-tuning of the circuit is necessary; therefore, a mathematical model of the control system will be derived and identified by data coming from ad hoc experiments performed on basic modules. Model simulations will be used to meet the design specifications of the biological controller, demonstrating that full characterization of basic parts is a major goal to predict the behavior of more complex circuits.
You can add captions too…




Laboratory for Biomedical Informatics | Centre of Tissutal Engineering

University of Pavia
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