Team:ETH Zurich/Modeling/SingleCell

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Single cell model

The model of our system consists of two connected parts: the band detector and the toggle switch. The band detector produces green fluorescent protein upon a detection of a certain range (band) of acetaldehyde concentration. After acetaldehyde concentration passes a certain threshold the toggle switch turns the system red (red fluorescent protein is expressed).

Brief overview of the model

Acetaldehyde from the smoke binds to AlcR and the formed complex then inhibits TetR. TetR inhibits LacI and CI. CI also inhibits LacI which inhibits GFP. This part of the circuit makes up the band detector. The Acetaldehyde-AlcR complex is considered as constant input to our system. By simulating with varying acetaldehyde concentrations we can see at which concentration is the band , i.e. at which concentrations GFP is produced. The connection to the switch is done by the

Band Detector

Bandpasseq.png

Toggle Switch

Quorum.png
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