Team:KAIT Japan/Project

From 2011.igem.org

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== '''Intro''' ==
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== '''Back Ground''' ==
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     We tried to overlap colony on colony. Generally, colony and colony don’t overlap and approach each other, because of the cell-cell communications. Bacterias also have a system, so called quorum sensing, to control of production of signal chemicals depend on the bacteria’s density.
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Bacteria detect the concentration of its friends, called Quorum Sensing, and the
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sensing system is one of the communication tools between microbes. It is related also
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    We pay attention quorum sensing system. Bacterias produce and secret autoinducer against other bacterias by quorum sensing system, as a result of the system, bacteria senses other bacterias. Most of Gram-negative bacterias make use of autoinducer named AHL. We applied E. coli to our experiment and we use aiia which is catabolic enzyme to inhibit AHL. We tried to make a recombinant bacteria to cancelled sensing of other bacterias and expected to form the colony of bacterias on the other bacterias.
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to formation of biofilm and to pathogenicity. As the Quorum Sensing of Gram-negative
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bacterias, Acyl-Homoserine Lactone ( AHL ) is released to recognize each other. 2007,
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the team of Chiba University made the vacteria production of aiia to decrease the AHL.
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We considered application of the system to make a colony layer on a colony layer by
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depressing of Quorum Sensing.
== Project Details==
== Project Details==

Revision as of 18:22, 5 October 2011

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Contents

Back Ground

Bacteria detect the concentration of its friends, called Quorum Sensing, and the sensing system is one of the communication tools between microbes. It is related also to formation of biofilm and to pathogenicity. As the Quorum Sensing of Gram-negative bacterias, Acyl-Homoserine Lactone ( AHL ) is released to recognize each other. 2007, the team of Chiba University made the vacteria production of aiia to decrease the AHL. We considered application of the system to make a colony layer on a colony layer by depressing of Quorum Sensing.

Project Details

Quorum Sensing

Quorum sensing is a system of stimulus and response correlated to population density. Many species of bacteria use quorum sensing to coordinate gene expression according to the density of their local population. In similar fashion, some social insects use quorum sensing to determine where to nest.


AHL

AiiA

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