Team:UNIPV-Pavia

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Revision as of 12:51, 11 July 2011

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UNIPV-Pavia

Ctrl+E: E. coli is nothing without control

One of the pivotal objectives of synthetic biology is to build complex gene networks with a predictable behavior by combining well-characterized basic modules. As a proof of concept of this fundamental, our project aims at designing and implementing in E. coli a quorum sensing-based control system, able to regulate the concentration of a signaling molecule (3OC6-HSL) via a negative feedback loop.
Mastering such a communication system can prove useful in fighting different infections arising from quorum sensing-communicating bacteria.
In order to obtain the desired output, fine-tuning of the circuit is necessary; therefore, a mathematical model of the control system will be derived and identified by data coming from ad hoc experiments on basic modules. Model simulations will be used to meet the design specifications of the biological controller, demonstrating that full characterization of basic parts is a major goal to predict the behavior of more complex circuits.

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+<p style="text-align:justify;">One of the pivotal objectives of synthetic biology is to build complex gene networks with a predictable behavior by combining well-characterized basic modules. As a proof of concept of this fundamental, our project aims at designing and implementing in E. coli a quorum sensing-based control system, able to regulate the concentration of a signaling molecule (3OC6-HSL) via a negative feedback loop.<br>
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+Mastering such a communication system can prove useful in fighting different infections arising from quorum sensing-communicating bacteria.<br>
-<p style="text-align:justify;"> Suspendisse pharetra auctor pharetra. Nunc a sollicitudin est. Curabitur ullamcorper gravida felis, sit amet scelerisque lorem iaculis sed. Donec vel neque in neque porta venenatis sed sit amet lectus. Fusce ornare elit nisl, feugiat bibendum lorem. Vivamus pretium dictum sem vel laoreet. In fringilla pharetra purus, semper vulputate ligula cursus in. Donec at nunc nec dui laoreet porta eu eu ipsum. Sed eget lacus sit amet risus elementum.</p>
+In order to obtain the desired output, fine-tuning of the circuit is necessary; therefore, a mathematical model of the control system will be derived and identified by data coming from ad hoc experiments on basic modules. Model simulations will be used to meet the design specifications of the biological controller, demonstrating that full characterization of basic parts is a major goal to predict the behavior of more complex circuits.</p>
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