Team:DTU-Denmark

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Revision as of 12:25, 14 July 2011

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You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples HERE.

You MUST have a team description page, a project abstract, a complete project description, a lab notebook, and a safety page. PLEASE keep all of your pages within your teams namespace.

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File:DTU-Denmark logo.png

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Project Description

Non-coding RNA is an active area of research with untapped possibilities for application in biotechnology. In prokaryotes a growing number of small RNA (sRNA) have revealed unsuspected layers of regulation.

We at the iGEM DTU-Denmark team are designing an sRNA based regulatory system compatible with the BioBrick standard. Our core ideas are inspired by a novel mechanism of sRNA mediated post-transcriptional regulation found in E. Coli and Salmonella. The naturally occurring system consists of a regulation topology where one sRNA inhibits another sRNA, which in turn inhibits a third RNA that is translated. The inhibitions might be codable on the sequence level and therefore the system may provide design solutions enabling efficient regulatory control and specificity towards any BioBrick module. To test whether this is the case, we are constructing a biological E. Coli model enabling us to control the synthesis of both sRNAs and measure the outcome of the regulatory system.

In interplay with the experimental efforts, we are setting up models to test hypotheses about the system and to guide the design process. Modeling should also provide a quantitative understanding useful for those who wish to employ our final BioBrick

File:DTU-Denmark team.png

Your team picture

Team Example

Home	Team	Official Team Profile	Project	Parts Submitted to the Registry	Modeling	Notebook	Safety	Attributions

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-''Tell us more about your project.  Give us background.  Use this as the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
+== Project Description ==
+Non-coding RNA is an active area of research with untapped possibilities for application in biotechnology. In prokaryotes a growing number of small RNA (sRNA) have revealed unsuspected layers of regulation.
+We at the iGEM DTU-Denmark team are designing an sRNA based regulatory system compatible with the BioBrick standard. Our core ideas are inspired by a novel mechanism of sRNA mediated post-transcriptional regulation found in E. Coli and Salmonella. The naturally occurring system consists of a regulation topology where one sRNA inhibits another sRNA, which in turn inhibits a third RNA that is translated. The inhibitions might be codable on the sequence level and therefore the system may provide design solutions enabling efficient regulatory control and specificity towards any BioBrick module. To test whether this is the case, we are constructing a biological E. Coli model enabling us to control the synthesis of both sRNAs and measure the outcome of the regulatory system.
+In interplay with the experimental efforts, we are setting up models to test hypotheses about the system and to guide the design process. Modeling should also provide a quantitative understanding useful for those who wish to employ our final BioBrick
 |[[Image:DTU-Denmark_team.png|right|frame|Your team picture]]
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