Team:DTU-Denmark

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         <h2>Tuning regulation with a non-coding RNA trap</h2>
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         <h2>Vision</h2>
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Small regulatory RNA is an active area of research with untapped possibilities for application in biotechnology. One such application could be the optimization and fine-tuning of synthetic biological circuits, which is currently a cumbersome process of trial and error. We have investigated a novel type of RNA regulation, where the inhibition caused by a small regulatory RNA is relieved by another RNA called trap-RNA. The system displays a large dynamic range and can uniquely target and repress any gene of interest providing unprecedented flexibility. We suspect that any level of repression is achievable by simply altering the sequences of the involved RNAs. Multiple such systems can coexist without interfering and are thus compatible with more complex designs. Furthermore the trap-RNA can be fused to any transcript in effect allowing any gene to act as an activator.
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Gene silencing is a fundamental technique in biology. It is currently a time-consuming process restricted to nonessential genes and a few bacteria. For more perspectives and possible solutions go to <a href="/Team:DTU-Denmark/Vision">project vision</a>.
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         <h2>Box 2</h2>
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         <h2>Project</h2>
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Non-coding RNA is an active area of research with untapped possibilities for application in biotechnology. In prokaryotes a growing number of small RNA (sRNA) have revealed unsuspected layers of regulation. Non-coding RNA is an active area of research with untapped possibilities for application in biotechnology. In prokaryotes a growing number of small RNA (sRNA) have revealed unsuspected layers of regulation.
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In this project a novel small RNA technology for gene silencing in bacteria is developed. We applied bioinformatics, experimental biology and mathematical modeling. For a full description go to <a href="/Team:DTU-Denmark/Project">project overview</a>.
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         <h2>This project is part of iGEM</h2>
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         <h2>Background</h2>
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        Read more on the <a href="https://2011.igem.org/Main_Page">iGEM Main Page</a>
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To help you understand the science of the project important concepts are explained. This covers small RNA, synthetic biology and more advanced topics. To get informed go to <a href="/Team:DTU-Denmark/Background_sRNA">background</a>.
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Latest revision as of 21:35, 21 September 2011

Vision

Gene silencing is a fundamental technique in biology. It is currently a time-consuming process restricted to nonessential genes and a few bacteria. For more perspectives and possible solutions go to project vision.

Project

In this project a novel small RNA technology for gene silencing in bacteria is developed. We applied bioinformatics, experimental biology and mathematical modeling. For a full description go to project overview.

Background

To help you understand the science of the project important concepts are explained. This covers small RNA, synthetic biology and more advanced topics. To get informed go to background.

Retrieved from "http://2011.igem.org/Team:DTU-Denmark"