Team:DTU-Denmark

From 2011.igem.org

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         <h2>What?</h2>
         <h2>What?</h2>
         <p>
         <p>
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In this project a novel small RNA technology for gene silencing in bacteria is developed. For more information see project overview.
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In this project a novel small RNA technology for gene silencing in bacteria is developed. The silencing is tunable to a large range of expression levels and can be applied to any gene in most bacteria. For more information go to project overview.
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         <h2>Why?</h2>
         <h2>Why?</h2>
         <p>
         <p>
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Gene knockout is a fundamental technique in biology. It is currently a time-consuming process restricted to nonessential genes. For more perspectives see project vision.
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Gene knockout is a fundamental technique in biology. It is currently a time-consuming process restricted to nonessential genes. For more perspectives go to project vision.
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         <h2>How?</h2>
         <h2>How?</h2>
         <p>
         <p>
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The developed technology consists of two small RNAs, which can be configured to target any gene by simply changing the sequence of the RNAs. The expression of the two RNAs controls the silencing of the target gene and can even target multiple targets.
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Inspired by the chitobiose system in E. coli we constructed a biological and mathematical model of the small RNA technology. For additional details go to technical stuff.
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         </p>
         </p>
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Revision as of 21:35, 19 September 2011

What?

In this project a novel small RNA technology for gene silencing in bacteria is developed. The silencing is tunable to a large range of expression levels and can be applied to any gene in most bacteria. For more information go to project overview.

Why?

Gene knockout is a fundamental technique in biology. It is currently a time-consuming process restricted to nonessential genes. For more perspectives go to project vision.

How?

Inspired by the chitobiose system in E. coli we constructed a biological and mathematical model of the small RNA technology. For additional details go to technical stuff.

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