Team:DTU-Denmark

From 2011.igem.org

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         <h2>What?</h2>
         <h2>What?</h2>
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In this project a novel sRNA technology for gene silencing in bacteria is developed. The silencing is tunable to a large range of expression levels and can be applied to any gene in most bacteria. The silencing can be turned on and off at any time.
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In this project a novel small RNA technology for gene silencing in bacteria is developed. For more information see project overview.
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         <h2>Why?</h2>
         <h2>Why?</h2>
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Gene knockout is a pivotal technique in biology. It is currently a time-consuming process of chromosomal knockout restricted to mostly nonessential genes. No method allows partial gene silencing and no method has applied sRNA to target genes of interest.
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Gene knockout is a fundamental technique in biology. It is currently a time-consuming process restricted to nonessential genes. For more perspectives see project vision.
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Revision as of 21:26, 19 September 2011

What?

In this project a novel small RNA technology for gene silencing in bacteria is developed. For more information see project overview.

Why?

Gene knockout is a fundamental technique in biology. It is currently a time-consuming process restricted to nonessential genes. For more perspectives see project vision.

How?

The developed technology consists of two small RNAs, which can be configured to target any gene by simply changing the sequence of the RNAs. The expression of the two RNAs controls the silencing of the target gene and can even target multiple targets.

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