Team:Edinburgh/Cellulases (MATLAB model)
From 2011.igem.org
Cellulases (MATLAB model)
The most important part of the biorefinery is the reactor where cellulose is converted to glucose. But accurately predicting how much is converted, using synergy between enzymes is difficult without literature to provide the ordinary differential equations (ODE's) and the kinetic parameters. Therefore this model only looks at the free floating enzyme approach (non-synergy). It is deterministic i.e non random and is set by a series of initial conditions.
Structure of model
The model is based on the ODE's and kinetic parameters outlines in, Kadam et al, 2004 [http://onlinelibrary.wiley.com/doi/10.1021/bp034316x/full Kadam et al, 2004].
References
- Kadam KL, Rydholm EC, McMillan JD (2004) [http://onlinelibrary.wiley.com/doi/10.1021/bp034316x/full Development and Validation of a Kinetic Model for Enzymatic Saccharification of Lignocellulosic Biomass]. Biotechnology Progress 20(3): 698–705 (doi: 10.1021/bp034316x).