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Team:Edinburgh/Biorefinery
From 2011.igem.org
Biorefinery
A feasibility study of the engineering design and economics of a biorefinery plant concerned with the synergistic breakdown of cellulose.
Contents |
What is a biorefinery?
A biorefinery is a processing plant that converts biological raw materials into a variety of products that can be used as industrial intermediates or sold directly to consumers. Biorefineries offer flexibility in both the types of products that can be made and the raw materials that can be used; flexibility that conventional chemical/food plants aren’t able to offer. However, for this technology to be successful it has to be integrated within a bio-based economy where its raw materials can be sourced both sustainably and cheaply.
Using synthetic biology, by creating BioBricks and incorporating them into genetically designed microorganisms, it should be possible to make products from biological feedstocks that range from food additives to chemicals.
This document develops a design for a biorefinery based on our iGEM project of synergistic cellulose breakdown. We examine one engineering design for this biorefinery with a detailed process flow diagram. An analysis of the economics of this plant is also made, investigating its required capital and projected profits. This detailed economic and technical investigation is part of our bigger feasibility study, and we see it as related in important ways to questions about what role synthetic biology might have in the future, and whether biorefineries are a realistic short-term application area for this technology.
Raw Materials
Building a biorefinery, and the investment required to do so, can only be justified if the procurement of its raw materials is done both economically and sustainably. There are very important questions about where these biological feedstocks should come from. Nicholas Peyret, from Scottish Enterprise, a public body which encourages economic development, asks,
“Can we take advantage of Scottish feedstock?” (Interview with Nicholas Peyret, 25/08/2011)
He says that more research is needed to analyse the potential of different Scottish feedstocks. But in principle it makes more sense than shipping biomass across the world for example, growing sugarcane in Brazil to export for industrial use in the United States or Europe. Eric Hoffman, Biotechnology Policy Officer for Friends of Earth asks,
“What happens if we start switching more and more land which is currently used in agriculture production and start shifting that for feedstock for synthetic bugs?” (Interview with Eric Hoffman, 11/08/2011)
His concerns shouldn’t be ignored in a bid to make synthetic biology commercially successful in the short term, but should be addressed with a careful rationale and with humility.
The raw material to be used in our proposed biorefinery is open for debate as the biorefinery is not constrained in the exact material but only in its source. Lignocellulose is the primary structural material in plants and is made up of hemicellulose, cellulose and lignin. The biorefinery will separate lignocellulose into its three constituents, and from cellulose then into glucose and the desired product.
Traditionally those sourcing lignocellulose biomass would look to softwoods, hardwoods and grasses. Biomass such as switchgrass, corn stover and sugar cane are popular options. But what if the biomass sourced is already waste and can be recycled? We suggest that old newspapers, furniture, straw and other lignocellulose- based waste could be possible input feedstocks. Commercially, this method could be significantly cheaper, but a challenge nonetheless to the contractors to find reliable sources at the necessary volumes. The biorefinery proposed by the Edinburgh iGEM team aims to use up to 700 kg/h of biomass, to make it commercially worthwhile. Current biorefineries operate at around 500 kg/h, with company Elsam Essential energy (European commission, 2004) looking do develop pilot lignocellulose plants of up to 1000 kg/h of biomass. 700 kg/h was assessed to be both realistic in the short to medium term and ensure good returns to any potential investor.
