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Team:Tokyo Metropolitan/Project
From 2011.igem.org
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| Project "BeE.coli" We propose the project "BeE.coli" as the micro injection system. We will make E.coli that moves in high speed to the target and kill it. We have been trying to put three different facility such as "speed up", "targeting", and "killing" by enhancing the flagellar movement, taking control of flagellar rotation, and sending killer gene to the target. | |
| Speeding Up Device makes E.coli to move in higher speed than usual. E.coli have HNS protein gene in their genome. HNS is an Escherichia coli nucleoid protein known only to function as a modulator of gene expression. Gina M. Donato said that specific single amino acid substitutions in H-NS caused an approximately 50% increase in flagellum rotational speed. So we have E.coli to express HNS mutant T108I gene with plasmid. | |
