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Team:Harvard/Project/Zinc Finger Background
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| - | + | =What are Zinc Finger Proteins (ZFPs)?= | |
| + | ==Function== | ||
| + | ZFPs are found commonly in nature as a class of special transcription factors that bind to DNA, thus regulating gene expression. | ||
| + | |||
| + | ==Structure== | ||
| + | ZFPs consist of smaller subunits called "fingers" which each contain a zinc finger binding helix that binds to unique DNA sequences. These fingers are linear and linked together by the "zinc finger backbone", a series of approximately 21 amino acids. | ||
| + | |||
| + | Cis2His2 ZFPs have three main structural components: | ||
| + | 1) Zinc finger binding helix | ||
| + | 2) Linker region | ||
| + | 3) Zinc ion that is coordinated by two cysteine residues and two histidine residues. | ||
| + | |||
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Revision as of 16:50, 25 September 2011
Overview | Bioinformatics | Chip-Based Library | Plasmid Construction | Selection Strain Engineering | Protocols
What are Zinc Finger Proteins (ZFPs)?
Function
ZFPs are found commonly in nature as a class of special transcription factors that bind to DNA, thus regulating gene expression.
Structure
ZFPs consist of smaller subunits called "fingers" which each contain a zinc finger binding helix that binds to unique DNA sequences. These fingers are linear and linked together by the "zinc finger backbone", a series of approximately 21 amino acids.
Cis2His2 ZFPs have three main structural components: 1) Zinc finger binding helix 2) Linker region 3) Zinc ion that is coordinated by two cysteine residues and two histidine residues.
