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Team:UPO-Sevilla/Project/Basic Flip Flop/Modeling/Toggle Switch
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<h1>Toggle Switch</h1> | <h1>Toggle Switch</h1> | ||
| - | + | <h2>Introduction</h2> | |
| - | + | <p>The next step in this point is to model the actuations that allow us to modify the state of the system, inducing a switch in the flip-flop.</p> | |
| + | |||
| + | <p>These actuators are:</p> | ||
| + | |||
| + | <ul> | ||
| + | <li><strong>Using a thermosensitive repressor protein</strong>. By increasing the temperature of the bacteria, the protein is rapidly degraded, thus helping the change.</li> | ||
| + | <li><strong>Adding IPTG</strong>. The IPTG molecules bind competitively to the other repressor. Therefore, the inhibition of the transcription by the repression is not permitted. The IPTG induction is achieved assuming a Hill kinetic for the ligand-binding.</li> | ||
| + | </ul> | ||
| + | |||
| + | |||
| + | |||
| + | <h2>Diagram</h2> | ||
| + | |||
| + | <p>Then, the model is complemented with 3 new elements:</p> | ||
| + | |||
</div> | </div> | ||
Revision as of 17:01, 20 September 2011
Toggle Switch
Introduction
The next step in this point is to model the actuations that allow us to modify the state of the system, inducing a switch in the flip-flop.
These actuators are:
- Using a thermosensitive repressor protein. By increasing the temperature of the bacteria, the protein is rapidly degraded, thus helping the change.
- Adding IPTG. The IPTG molecules bind competitively to the other repressor. Therefore, the inhibition of the transcription by the repression is not permitted. The IPTG induction is achieved assuming a Hill kinetic for the ligand-binding.
Diagram
Then, the model is complemented with 3 new elements:
Sponsors
