Team:UPO-Sevilla/Project/Improving Flip Flop/Modeling/Equations

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                             <h1>Equations</h1>
                             <h1>Equations</h1>
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                            <p>We define the reactions and the parameters involved in the system.</p>
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                            <p>First we show a summary of the species:</p>
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                            <p>Species:</p>
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                            <ul>
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                            <li>Promoter1</li>
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                            <li>Promoter2</li>
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                            <li>mRNA1</li>
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                            <li>mRNA2</li>
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                            <li>Repressor1/r1</li>
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                            <li>Repressor2</li>
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                            <li>Ribosomes</li>
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                            <li>IPTG</li>
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                            <li>asRNA</li>
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                            <li>Protease</li>
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                            </ul>
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                            <p>Parameters:</p>
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                            <ul>
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                            <li>Km : Michaelis constant of transcription</li>
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                            <li>Kmu: Michaelis constant of translation</li>
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                            <li>δ: mRNA rate of degradation</li>
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                            <li>λ: mRNA maximum rate of synthesis</li>
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                            <li>k: Repressor rate of synthesis</li>
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                            <li>Kiu: Dissociation constant of repression</li>
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                            <li>γ: Cooperativity of inhibition by the repressor</li>
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                            <li>Ki: Binding constant for IPTG to the repressor</li>
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                            <li>K: Multimerization constant</li>
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                            <li>η: Maximum number of bound IPTG molecule per repressor</li>
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                            <li>ktemp: Degradation constant due to the temperature effect</li>
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                            <li>kprs: Rate constant for proteolysis kinetic</li>
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                            <li>kinh: Rate constant for inhibition of translation</li>
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                            <li>δ<sub>3</sub>: Degradation rate of asRNA</li>
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                            <li>kptsa: Degradation rate of Protease</li>
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                            </ul>
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                            <p></p>
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                            <p></p>
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                            <p></p>
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                            <p></p>
                              
                              
                              
                              

Revision as of 00:15, 20 September 2011

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Equations

We define the reactions and the parameters involved in the system.

First we show a summary of the species:

Species:

  • Promoter1
  • Promoter2
  • mRNA1
  • mRNA2
  • Repressor1/r1
  • Repressor2
  • Ribosomes
  • IPTG
  • asRNA
  • Protease

Parameters:

  • Km : Michaelis constant of transcription
  • Kmu: Michaelis constant of translation
  • δ: mRNA rate of degradation
  • λ: mRNA maximum rate of synthesis
  • k: Repressor rate of synthesis
  • Kiu: Dissociation constant of repression
  • γ: Cooperativity of inhibition by the repressor
  • Ki: Binding constant for IPTG to the repressor
  • K: Multimerization constant
  • η: Maximum number of bound IPTG molecule per repressor
  • ktemp: Degradation constant due to the temperature effect
  • kprs: Rate constant for proteolysis kinetic
  • kinh: Rate constant for inhibition of translation
  • δ3: Degradation rate of asRNA
  • kptsa: Degradation rate of Protease

Retrieved from "http://2011.igem.org/Team:UPO-Sevilla/Project/Improving_Flip_Flop/Modeling/Equations"