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Team:Paris Bettencourt
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<center><a href="https://2011.igem.org/File:BY_elec_small1.png"><img src="https://static.igem.org/mediawiki/2011/0/08/BY_elec_small1.png" style="width:40%; margin:15px;"></a><a href="https://2011.igem.org/File:BY_fluo_small1.png"><img src="https://static.igem.org/mediawiki/2011/d/d6/BY_fluo_small1.png" style="width:40%; margin:15px;"></a> | <center><a href="https://2011.igem.org/File:BY_elec_small1.png"><img src="https://static.igem.org/mediawiki/2011/0/08/BY_elec_small1.png" style="width:40%; margin:15px;"></a><a href="https://2011.igem.org/File:BY_fluo_small1.png"><img src="https://static.igem.org/mediawiki/2011/d/d6/BY_fluo_small1.png" style="width:40%; margin:15px;"></a> | ||
| - | <p><b><u>Fig1:</u> Extracts from the Dubey-Ben-Yehuda article) <a href="http://bms.ucsf.edu/sites/ucsf-bms.ixm.ca/files/marjordan_06022011.pdf">[1]</a> | + | <p><b><u>Fig1:</u> Extracts from the Dubey-Ben-Yehuda article) <a href="http://bms.ucsf.edu/sites/ucsf-bms.ixm.ca/files/marjordan_06022011.pdf">[1]</a></b></p></center> |
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<p>Our goal this summer was to see how the synthetic biology community could harness the power of <a href="https://2011.igem.org/Team:Paris_Bettencourt/Potential_Application">amorphous computation</a> and <a href="https://2011.igem.org/Team:Paris_Bettencourt/Potential_Application">metabolic engineering</a> of this nanotube network. Each cell is potentially a tiny individual computer linked directly and only to its closest neighbours. The existence of the so-called nanotubes is however still debated.</p> | <p>Our goal this summer was to see how the synthetic biology community could harness the power of <a href="https://2011.igem.org/Team:Paris_Bettencourt/Potential_Application">amorphous computation</a> and <a href="https://2011.igem.org/Team:Paris_Bettencourt/Potential_Application">metabolic engineering</a> of this nanotube network. Each cell is potentially a tiny individual computer linked directly and only to its closest neighbours. The existence of the so-called nanotubes is however still debated.</p> | ||
Revision as of 11:55, 7 September 2011
Welcome to the iGEM Paris Bettencourt 2011 wiki
Using synthetic biology to investigate newly discovered biological phenomena
The recent discovery of nanotubes between individual B.subtilis by Dubey and Ben-Yehuda spiked our interest. Through very detailed and advanced microscopy, they showed nanotubes forming between cells and that a wide rande of proteins could pass through this communication channel (GFP, calcein, antibiotics, ...). They also showed signs of communication between B.subtilis and E.Coli, another species entirely. With these synthetic-biology-friendly bacterium and a potentially non-specific cell-to-cell transportation system, the possibilities for designing new systems seem endless!
Fig1: Extracts from the Dubey-Ben-Yehuda article) [1]
Our goal this summer was to see how the synthetic biology community could harness the power of amorphous computation and metabolic engineering of this nanotube network. Each cell is potentially a tiny individual computer linked directly and only to its closest neighbours. The existence of the so-called nanotubes is however still debated.
We decided therefore to investigate this phenomenon and characterize it using the tools synthetic biology provides. We created new B.subtilis BioBricks, filling a surprising hole in the part registry since very few iGEM teams worked on this organism in the past. Those BioBricks were used to provide new evidence supporting the existence of a nanotube network.
See our work!
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The Team:
We are fifteen parisian students coming from many different disciplines who came together to participate to the iGEM competition. Come and meet the Team. |
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The project: In February, a team lead by Dubey and Ben-Yehuda discovered an extraordinary new form of communication for bacteria: nanotubes between individual cells! This type of link is well known between eukaryotic cells, but here it was observed between cells widely used by synthetic biologists (Bacillus subtilis). We decided to investigate this new communication way in details using the tools synthetic biology can design. You can find out more about our project in the Project section. |
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The Tools:
We are developping new tools to help the biologis to develop his own genetic circuits. With BioHave, you can browse a biologic part database by systhematic method. You programm the behavior you want and BioHave gives you the bests combination of parts to build it! |
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The values:
Ethic and safety are two main concern when building genetically engineered organism. You can visit our Human practice work and our safety page. |
