Team:Tokyo Metropolitan

From 2011.igem.org

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<font size="4"><b>Our project : Bee.coli</b></font><br><br>
<font size="4"><b>Our project : Bee.coli</b></font><br><br>
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We propose the project "Bee.coli" as the micro injection system. <br>
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We propose the project "BeE.coli" as a micro injection system. <br>
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Bee.coli has the ability to move fast and target the pathogens concentrated area. <br>
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BeE.coli has the abilities to move fast and target pathogens concentrated area. <br>
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Getting close to the pathogens, it sends the killer gene to them with conjugation. Then the pathogens will be killed.<br>
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Getting close to pathogens, it sends the killer gene to them with conjugation. Then pathogens will be killed.<br>
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To accomplish this project, we planed to add three function to E.coli.<br>
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<br>
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First, expression of the mutant HNS proteins enable E.coli to move 1.5 times faster. This contributes to increasing the frequency of conjugation.<br>
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To accomplish this project, we planned to add three functions to E.coli.<br>
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Second function is new taxis for AHL. We make the target bacteria as the model of the pathogen, and they produce AHL. <br>
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First, expression of the mutant H-NS proteins enables E.coli to move faster. This contributes to increasing the frequency of conjugation.<br>
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Bee.coli will often go for where high concentration of AHL. That is, where the target bacteria are concentrated. <br>
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Second function is new taxis for AHL. We make the target bacteria as a model of pathogens, and they produce AHL. BeE.coli goes for the area where high concentrations of AHL that means concentration of target bacteria. <br>
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Last, the killer gene with the conjugative plasmid. Since Bee.coli also has the anti killer gene, it is alive and kill the pathogens with conjugation.<br>
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Last, BeE.coli kills pathogens by sending the killer gene with the conjugative plasmid. BeE.coli has the anti killer gene repressing the killer gene.<br>
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In the future, Bee.coli will help the medical or environmental scenes.<br>
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In the future, BeE.coli will be useful for medical scenes.<br>
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Revision as of 09:37, 4 September 2011

Our project : Bee.coli

We propose the project "BeE.coli" as a micro injection system.
BeE.coli has the abilities to move fast and target pathogens concentrated area.
Getting close to pathogens, it sends the killer gene to them with conjugation. Then pathogens will be killed.

To accomplish this project, we planned to add three functions to E.coli.
First, expression of the mutant H-NS proteins enables E.coli to move faster. This contributes to increasing the frequency of conjugation.
Second function is new taxis for AHL. We make the target bacteria as a model of pathogens, and they produce AHL. BeE.coli goes for the area where high concentrations of AHL that means concentration of target bacteria.
Last, BeE.coli kills pathogens by sending the killer gene with the conjugative plasmid. BeE.coli has the anti killer gene repressing the killer gene.

In the future, BeE.coli will be useful for medical scenes.

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