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Team:UQ-Australia
From 2011.igem.org
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| - | |The human circadian rhythm drives many important processes in the body in accordance with the sleep/wake cycle. A characteristic of this biological clock is the periodic oscillation of gene expression. Current parts in the Registry designed to regulate periodic oscillations of gene expression have shown limited success. | + | {|style="width:100%;" border="0" cellpadding="10" cellspacing="0" |
| + | |rowspan="2"|The human circadian rhythm drives many important processes in the body in accordance with the sleep/wake cycle. A characteristic of this biological clock is the periodic oscillation of gene expression. Current parts in the Registry designed to regulate periodic oscillations of gene expression have shown limited success. | ||
Here we demonstrate a biological clock being standardised as a set of BioBrick parts. | Here we demonstrate a biological clock being standardised as a set of BioBrick parts. | ||
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Our network is controlled by an engineered promoter, Plac/ara, which features both an activator and a repressor domain. This controls the production of downstream genes to activate other inducible promoters, pBAD and GlnAp2, eventually leading to the production of a repressor protein, lacI, which inhibits Plac/ara, resulting in oscillatory expression. This project shows the feasibility of standardising the biological clock in E. coli and grounds further development for applications in regulated drug/hormone delivery and ion channel control. | Our network is controlled by an engineered promoter, Plac/ara, which features both an activator and a repressor domain. This controls the production of downstream genes to activate other inducible promoters, pBAD and GlnAp2, eventually leading to the production of a repressor protein, lacI, which inhibits Plac/ara, resulting in oscillatory expression. This project shows the feasibility of standardising the biological clock in E. coli and grounds further development for applications in regulated drug/hormone delivery and ion channel control. | ||
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Find us on [http://www.facebook.com/pages/UQ-iGEM-2011/174356539258535 Facebook]! | Find us on [http://www.facebook.com/pages/UQ-iGEM-2011/174356539258535 Facebook]! | ||
| + | ! width="125" |[[File:IGEM basic Logo stylized.png|125x125px|link=https://2011.igem.org]] | ||
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|[[File:UQ-Australia_logo_2011.png|125x125px|link=https://2011.igem.org/Team:UQ-Australia]] | |[[File:UQ-Australia_logo_2011.png|125x125px|link=https://2011.igem.org/Team:UQ-Australia]] | ||
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Revision as of 12:01, 4 October 2011
