Team:Valencia

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    <li><a href="https://2010.igem.org/Team:Valencia/Achievements">Achievements</a></li>
 
-
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<p>W.C. Cleaner </p>
 
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<p>The aim of our team is to develop a biological alternative for disinfecting contaminated water using synthetic biology.  Our target microorganisms are enterobacteria, but we'll focus in treating E. coli contaminated water. We will kill E. coli by means of colicin, an antimicrobial peptide produced by modified strains of Escherichia coli that are resistant to these proteins. The activity of these peptides will be controlled by a biological pH-stat that will use cyanobacteria to control pH.
 
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We plan to deliver a DIY kit that can disinfect water from enterobacteria and will be a prototype platform for killing other pathogens that cause diseases such as cholera, diarrhea and typhoid fever, ending in more than 2 million deaths in the last year according to the WHO Guidelines for Drinking-Water Quality (World Health Organization, 2011).
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<div class=col_left_top>Water Colicin Cleaner: disinfected water by E. coli</div><!-- fin clase col_left_top-->
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<p>Water Colicin Cleaner is a biological alternative for disinfecting contaminated water using synthetic biology. We kill targeted pathogens by means of antimicrobial peptides in Escherichia coli. As a proof of concept we have chosen to aim for enterobacteria, focusing on E. coli contaminated water, as a proxy of fecal water. The cleaning of E. coli will be possible thanks to the colicin protein. The activity of these proteins will be controlled by a biological pH-stat, using light-driven cyanobacteria to control pH of the media.</p>
 +
 
 +
<p>We will deliver a DIY kit as a prototype platform for killing pathogens responsible of diseases such as cholera, diarrhea and typhoid fever, ending with more than 2 million deaths in the last year according to the 2011 WHO Guidelines for Drinking-Water Quality.</p>
 +
 
 +
<p>W.C. Cleaner is an effective, low-cost device, that will help people that struggle to find pathogen-free drinking water avoid important diseases.</p> </div><!-- fin clase col_left_top-->
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<img src="https://static.igem.org/mediawiki/2011/b/b1/Valencia_Upvtranspa.gif"/ width="150"/>
 +
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 +
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Latest revision as of 03:03, 22 September 2011

Valencia Bannerv4.jpg



Water Colicin Cleaner: disinfected water by E. coli

Water Colicin Cleaner is a biological alternative for disinfecting contaminated water using synthetic biology. We kill targeted pathogens by means of antimicrobial peptides in Escherichia coli. As a proof of concept we have chosen to aim for enterobacteria, focusing on E. coli contaminated water, as a proxy of fecal water. The cleaning of E. coli will be possible thanks to the colicin protein. The activity of these proteins will be controlled by a biological pH-stat, using light-driven cyanobacteria to control pH of the media.

We will deliver a DIY kit as a prototype platform for killing pathogens responsible of diseases such as cholera, diarrhea and typhoid fever, ending with more than 2 million deaths in the last year according to the 2011 WHO Guidelines for Drinking-Water Quality.

W.C. Cleaner is an effective, low-cost device, that will help people that struggle to find pathogen-free drinking water avoid important diseases.

Who we are

Retrieved from "http://2011.igem.org/Team:Valencia"