Team:Missouri Miners

From 2011.igem.org

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<h1>Project Center</h1><br />
 
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<p class="sectionheader"><b>Glucose Sensor Project</b></p>
 
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<h1>Welcome to the Missouri Miners Wiki page! </h1><br />
<h1>Welcome to the Missouri Miners Wiki page! </h1><br />
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<p class="sectionheader"><b>Project Background</b></p>
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The Team of 2011
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Type one diabetes is characterized by the body’s inability to produce insulin and is caused by the death or malfunction of the β-cells in the pancreas. Insulin is the hormone that decreases the blood glucose concentration by inducing the cellular intake of glucose. 
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Insulin is produced in the Islets of Langerhans (a section of the pancreas) where glucose in the blood is detected.  β-cells in this region produce insulin by monitoring the ratio of ATP (adenosine triphosphate) versus  ADP (adenosine diphosphate).  When the ATP level is increased the K+ channels close, creating an increase of Ca+ ions in the cell.  The unbalance of ions signals the golgi complex to secrete insulin. If the β-cells die or malfunction then insulin cannot be produced.  (http://www.abcam.com/index.html?pageconfig=resource&rid=10602&pid=7)
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<p>We are the Missouri Miners from Missouri University of Science and Technology.  Our team formed in 2007 and we've been working hard developing iGEM projects ever since.  In the beginning, the team only had a handful of people but, recently, we have grown to 30 hardworking members.</p>
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<p class="sectionheader"><b>Project Justification</b></p>
 
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In the United States alone, it is estimated that 3 million people are affected by type one diabetes.  Complications that arise due to this disease include heart disease, stroke, high blood pressure, blindness, kidney disease, and neuropathy.  The American Diabetes Association has estimated that diabetes costs America over $200 billion per year in diagnosis and treatment (http://www.diabetes.org ). 
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<p>Our team is a student organization at S&T and we have been working hard to establish ourselves among the other well known student groups.   We are also working towards becoming S&T's newest Student Design Team.  Being at a science and technology university, Design Teams have a strong tradition on our campus and are highly respected.   We hope to bring a new design aspect to our school and promote the usefulness of synthetic biology.</p>
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<p class="sectionheader"><b>Project Goal</b></p>
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Our goal is to model a system that can measure glucose levels and produce insulin as needed.  In the future, this system could lead to cheaper blood glucose testing devices or a economic and efficient insulin pump.
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To achieve this goal we are utilizing the EnvZ-OmpR signal transduction pathway.  This pathway is endogenous to E.Coli and has been well characterized.  EnvZ is a osmolarity sensor on the inner membrane of E.Coli.  When glucose is added to the environment it induces a change in osmolarity and activates EnvZ.  EnvZ then phosphorylates the OmpR transcription factor. When OmpR is phosphorylated it binds to the OmpR promoter and recruits RNA polymerase to begin downstream transcription. 
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<h1>Test</h1><br />
 
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<p class="sectionheader"><b>Testing</b></p>
 
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The Team of 2011
 
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<p>We are very excited to participate in the iGEM 2011 Jamboree!</p>
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Latest revision as of 05:48, 28 September 2011



Welcome to the Missouri Miners Wiki page!


The Team of 2011


We are the Missouri Miners from Missouri University of Science and Technology. Our team formed in 2007 and we've been working hard developing iGEM projects ever since. In the beginning, the team only had a handful of people but, recently, we have grown to 30 hardworking members.


Our team is a student organization at S&T and we have been working hard to establish ourselves among the other well known student groups. We are also working towards becoming S&T's newest Student Design Team. Being at a science and technology university, Design Teams have a strong tradition on our campus and are highly respected. We hope to bring a new design aspect to our school and promote the usefulness of synthetic biology.


We are very excited to participate in the iGEM 2011 Jamboree!


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