Team:DTU-Denmark

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         <h2>What?</h2>
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         <h2>Vision</h2>
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In this project a novel sRNA technology for gene silencing in bacteria is developed. The silencing is tunable to a large range of expression levels and can be applied to any gene in most bacteria. The silencing can be turned on and off at any time.
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Gene silencing is a fundamental technique in biology. It is currently a time-consuming process restricted to nonessential genes and a few bacteria. For more perspectives and possible solutions go to <a href="/Team:DTU-Denmark/Vision">project vision</a>.
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         <h2>Why?</h2>
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         <h2>Project</h2>
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Gene knockout is a pivotal technique in biology. It is currently a time-consuming process of chromosomal knockout restricted to mostly nonessential genes. No method allows partial gene silencing and no method has applied sRNA to target genes of interest.
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In this project a novel small RNA technology for gene silencing in bacteria is developed. We applied bioinformatics, experimental biology and mathematical modeling. For a full description go to <a href="/Team:DTU-Denmark/Project">project overview</a>.
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         <h2>How?</h2>
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         <h2>Background</h2>
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The developed technology consists of two small RNAs, which can be configured to target any gene by simply changing the sequence of the RNAs. The expression of the two RNAs controls the silencing of the target gene and can even target multiple targets.
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To help you understand the science of the project important concepts are explained. This covers small RNA, synthetic biology and more advanced topics. To get informed go to <a href="/Team:DTU-Denmark/Background_sRNA">background</a>.
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Latest revision as of 21:35, 21 September 2011

Vision

Gene silencing is a fundamental technique in biology. It is currently a time-consuming process restricted to nonessential genes and a few bacteria. For more perspectives and possible solutions go to project vision.

Project

In this project a novel small RNA technology for gene silencing in bacteria is developed. We applied bioinformatics, experimental biology and mathematical modeling. For a full description go to project overview.

Background

To help you understand the science of the project important concepts are explained. This covers small RNA, synthetic biology and more advanced topics. To get informed go to background.

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