Team:Harvard/Human Practices/Timeline

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Revision as of 23:33, 28 October 2011

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IP and Open Source Technology | Letter to Representatives

Zinc Finger Historical Timeline

  • Discovery of the zinc finger protein

    Sir Aaron Klug first identifies the repeated binding motif in Transcription Factor IIIA and is the first to use the term ‘zinc finger’.

  • First crystal structure of a zinc finger

    Carl Pabo and Nikola Pavletich of Johns Hopkins University solve the crystal structure of zif268, now the most-commonly studied zinc finger.

  • CEO Edward Lanphier founds Sangamo Biosciences

    Edward Lanphier leaves Somatix Therapy Corporation and makes a deal for exclusive rights to the work of Srinivan Chandrasegaran of Johns Hopkins University who combined the Fok I nuclease with zinc fingers.

  • Srinivasan Chandrasegaran successfully fuses Fok I nuclease to zinc fingers

    Attaching nuclease proteins to zinc fingers opened up possibilities for future research in gene therapy by allowing researchers to directly modify the genome though nuclease cutting.

  • Sangamo enters the public sector

  • Sangamo patents zinc finger nuclease technology

    Sangamo's patent, titled "Nucleic acid binding proteins (zinc finger proteins design rules)", ensures that any use or production of zinc fingers with attached nucleases is the intellectual property of Sangamo.

  • Rapid open source production of zinc finger nucleases becomes available

    Researcher Keith Joung of Harvard University and Mass. General Hospital develops a method for making zinc finger nuclease proteins that bind to custom target sequences.

  • Sangamo and Sigma-Aldrich sign licensing deal for sale of zinc finger nuclease proteins

    The license allows Sigma-Aldrich to sell custom zinc finger nuclease protein pairs for approximately $30,000 each.

  • Context-dependency improves open-source zinc finger engineering

    Keith Joung publishes tables of zinc finger binding sites that account for context-dependent effects and can be rearranged to form custom zinc finger proteins that bind to a variety of DNA sequences.

  • Harvard iGEM develops a novel method to engineer custom zinc fingers

    Harvard iGEM uses novel integration of existing technologies for rapid, massive production of custom zinc fingersWe have developed a rapid, comparatively low-cost, open source method for making thousands of custom zinc fingers by integrating MAGE, lambda red, and chip-based synthesis technologies.

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