Team:UQ-Australia

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|rowspan="2"|The human circadian rhythm drives many important processes in the body in accordance with the sleep/wake cycle. A characteristic of this biological clock is the periodic oscillation of gene expression. Current parts in the Registry designed to regulate periodic oscillations of gene expression have shown limited success.
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Here we demonstrate the feasibility a biological clock being standardised as a set of BioBrick parts.
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Our network is controlled by an engineered promoter, Plac/ara, which features both an activator and a repressor domain. This controls the production of downstream genes to activate other inducible promoters, pBAD and GlnAp2, eventually leading to the production of a repressor protein, lacI, which inhibits Plac/ara, resulting in oscillatory expression. This project shows the feasibility of standardising the biological clock in E. coli and grounds further development for applications in regulated drug/hormone delivery and ion channel control.
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You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
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[[File:Logo facebook.jpg|200px|link=http://www.facebook.com/UQiGEM.2011]]
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We are the iGEM Team from the University of Queensland, Brisbane, Australia.
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|[[File:UQ-Australia_logo_2011.png|125x125px|link=https://2011.igem.org/Team:UQ-Australia]]
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''During the year we will be working with researchers from a diverse range of disciplines to create our own genetically engineered machine.''
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|[[Image:UQ-Australia_team.png|right|frame|Your team picture]]
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|align="center"|[[Team:UQ-Australia | Team Example]]
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'''NB: wiki best viewed on Chrome, Firefox or Safari.'''
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!align="center"|[[Team:UQ-Australia|Home]]
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!align="center"|[[Team:UQ-Australia/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2011&team_name=UQ-Australia Official Team Profile]
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!align="center"|[[Team:UQ-Australia/Project|Project]]
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!align="center"|[[Team:UQ-Australia/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:UQ-Australia/Modeling|Modeling]]
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!align="center"|[[Team:UQ-Australia/Notebook|Notebook]]
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!align="center"|[[Team:UQ-Australia/Safety|Safety]]
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!align="center"|[[Team:UQ-Australia/Attributions|Attributions]]
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Latest revision as of 00:32, 6 October 2011




The human circadian rhythm drives many important processes in the body in accordance with the sleep/wake cycle. A characteristic of this biological clock is the periodic oscillation of gene expression. Current parts in the Registry designed to regulate periodic oscillations of gene expression have shown limited success.

Here we demonstrate the feasibility a biological clock being standardised as a set of BioBrick parts.

Our network is controlled by an engineered promoter, Plac/ara, which features both an activator and a repressor domain. This controls the production of downstream genes to activate other inducible promoters, pBAD and GlnAp2, eventually leading to the production of a repressor protein, lacI, which inhibits Plac/ara, resulting in oscillatory expression. This project shows the feasibility of standardising the biological clock in E. coli and grounds further development for applications in regulated drug/hormone delivery and ion channel control.

Logo facebook.jpg

IGEM basic Logo stylized.png
UQ-Australia logo 2011.png


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