Process Details

Hence, based on the market research,
The amount of product needed to meet the market requirement
= 1,000,000 treatments per yr × 0.005g per treatment = 5 kg per year
Assume: 20 batches per year
Final product yield per batch = 5 kg/20 = 0.25 kg

Figure 1. Comparison between the Current and Novel Bioprocesses.
Left: Flow Sheet of Current DNA Vaccine Manufacturing Process
Right: Flow Sheet of Novel DNA Vaccine Manufacturing Process with E.coili

(Abbreviations: UF/DF, Ultrafiltration/Diafiltration; AEC, Anion Exchange Chromatography; SEC, Size Exclusion Chromatography.)