Team:Wageningen UR/Project/ModelingProj1
From 2011.igem.org
(→Modeling synchronized oscillations) |
(→Modeling synchronized oscillations) |
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=== Mathematical model of the Hasty construct === | === Mathematical model of the Hasty construct === | ||
- | Since our BioBricked oscillatory system is based on the circuit published by Danino et al. in the paper “A synchronized quorum of genetic clocks”, our first model of the system is a reproduction of the mathematical model in the | + | Since our BioBricked oscillatory system is based on the circuit published by Danino et al. in the paper “A synchronized quorum of genetic clocks”, our first model of the system is a reproduction of the mathematical model in the supplementary information accompanying the publication mentioned. In their simulations, Danino et al. used a set of four delay differential equations, which we also used as starting point for our modeling work. |
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[[File:Equations_hasty_WUR.png|350px|left]] | [[File:Equations_hasty_WUR.png|350px|left]] | ||
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As can be seen in the GUI, the new variables which can be changed are now the both activators IPTG and aTc. The parameters used are still in arbitrary units and the values not yet verified with wet lab experiments. However, some | As can be seen in the GUI, the new variables which can be changed are now the both activators IPTG and aTc. The parameters used are still in arbitrary units and the values not yet verified with wet lab experiments. However, some | ||
- | + | Links and references: | |
[http://www.nature.com/nature/journal/v463/n7279/abs/nature08753.html Danino et al. 2010] | [http://www.nature.com/nature/journal/v463/n7279/abs/nature08753.html Danino et al. 2010] | ||
+ | [http://www.nature.com/nature/journal/v463/n7279/suppinfo/nature08753.html Supplementary information] | ||
[[Team:Wageningen_UR/Project/ModelingProj1#Modeling_synchronized_oscillations| back to top]] | [[Team:Wageningen_UR/Project/ModelingProj1#Modeling_synchronized_oscillations| back to top]] | ||
}} | }} |
Revision as of 18:57, 21 September 2011