Team:Tokyo Metropolitan/test3

From 2011.igem.org

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<font size="4"><b>Our project : BeE.coli</b></font><br><br>
 
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We propose the project "BeE.coli" as a micro injection system. <br>
 
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BeE.coli has the abilities to move fast and target pathogens concentrated area.  <br>
 
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Getting close to pathogens, it sends the killer gene to them with conjugation. Then pathogens will be killed.<br>
 
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To accomplish this project, we planned to add three functions to E.coli.<br>
 
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First, expression of the mutant H-NS proteins enables E.coli to move faster. This contributes to increasing the frequency of conjugation.<br>
 
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Second function is new taxis for AHL. We make the target bacteria as a model of pathogens, and they produce AHL. BeE.coli goes for the area where high concentrations of AHL that means concentration of target bacteria. <br>
 
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Last, BeE.coli kills pathogens by sending the killer gene with the conjugative plasmid. BeE.coli has the anti killer gene repressing the killer gene.<br>
 
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In the future, BeE.coli will be useful for medical scenes.<br>
 
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Revision as of 16:52, 27 September 2011