Team:Harvard/Human Practices/Timeline

From 2011.igem.org

(Difference between revisions)
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<ul id="dates">
<ul id="dates">
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<li><a href="#" title="Test1">1900</a></li>
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<li><a href="#" title="Test1">1985</a></li>
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<li><a href="#" title="Test2">1930</a></li>
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<li><a href="#" title="Test2">1991</a></li>
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<li><a href="#">1944</a></li>
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<li><a href="#">1995</a></li>
-
<li><a href="#">1950</a></li>
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<li><a href="#">1996</a></li>
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<li><a href="#">1971</a></li>
+
<li><a href="#">2000</a></li>
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<li><a href="#">1977</a></li>
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<li><a href="#">2004</a></li>
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<li><a href="#">1989</a></li>
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<li><a href="#">2008</a></li>
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<li><a href="#">1999</a></li>
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<li><a href="#">2009</a></li>
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+
-
<li><a href="#">2001</a></li>
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<li><a href="#">2011</a></li>
<li><a href="#">2011</a></li>
 +
 +
<li><a href="#">Summer 2011</a></li>
</ul>
</ul>
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<ul id="issues">
<ul id="issues">
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<li id="#1900">
+
<li id="#1985">
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/1.png" width="256" height="256" />
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/1.png" width="256" height="256" />
-
<h1>1900</h1>
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<h1>Discovery of the zinc finger protein</h1>
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<p>Donec semper quam scelerisque tortor dictum gravida. In hac habitasse platea dictumst. Nam pulvinar, odio sed rhoncus suscipit, sem diam ultrices mauris, eu consequat purus metus eu velit. Proin metus odio, aliquam eget molestie nec, gravida ut sapien. Phasellus quis est sed turpis sollicitudin venenatis sed eu odio. Praesent eget neque eu eros interdum malesuada non vel leo. Sed fringilla porta ligula.</p>
+
<p>Sir Aaron Klug first identifies the repeated binding motif in Transcription Factor IIIA and is the first to use the term ‘zinc finger’.</p>
</li>
</li>
-
<li id="#1930">
+
<li id="#1991">
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/2.png" width="256" height="256" />
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/2.png" width="256" height="256" />
-
<h1>1930</h1>
+
<h1>First crystal structure of a zinc finger</h1>
-
<p>Donec semper quam scelerisque tortor dictum gravida. In hac habitasse platea dictumst. Nam pulvinar, odio sed rhoncus suscipit, sem diam ultrices mauris, eu consequat purus metus eu velit. Proin metus odio, aliquam eget molestie nec, gravida ut sapien. Phasellus quis est sed turpis sollicitudin venenatis sed eu odio. Praesent eget neque eu eros interdum malesuada non vel leo. Sed fringilla porta ligula.</p>
+
<p>Carl Pabo and Nikola Pavletich of Johns Hopkins University solve the crystal structure of zif268, now the most-commonly studied zinc finger.</p>
</li>
</li>
-
<li id="#1944">
+
<li id="#1995">
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/3.png" width="256" height="256" />
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/3.png" width="256" height="256" />
-
<h1>1944</h1>
+
<h1>CEO Edward Lanphier founds Sangamo Biosciences</h1>
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<p>Donec semper quam scelerisque tortor dictum gravida. In hac habitasse platea dictumst. Nam pulvinar, odio sed rhoncus suscipit, sem diam ultrices mauris, eu consequat purus metus eu velit. Proin metus odio, aliquam eget molestie nec, gravida ut sapien. Phasellus quis est sed turpis sollicitudin venenatis sed eu odio. Praesent eget neque eu eros interdum malesuada non vel leo. Sed fringilla porta ligula.</p>
+
<p>Edward Lanphier leaves Somatix Therapy Corporation and makes a deal for exclusive rights to the work of Srinivan Chandrasegaran of Johns Hopkins University who combined the Fok I nuclease with zinc fingers.</p>
</li>
</li>
-
<li id="#1950">
+
<li id="#1996">
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/4.png" width="256" height="256" />
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/4.png" width="256" height="256" />
-
<h1>1950</h1>
+
<h1>Srinivasan Chandrasegaran publishes research on fusing Fok I nuclease to zinc finger proteins</h1>
-
<p>Donec semper quam scelerisque tortor dictum gravida. In hac habitasse platea dictumst. Nam pulvinar, odio sed rhoncus suscipit, sem diam ultrices mauris, eu consequat purus metus eu velit. Proin metus odio, aliquam eget molestie nec, gravida ut sapien. Phasellus quis est sed turpis sollicitudin venenatis sed eu odio. Praesent eget neque eu eros interdum malesuada non vel leo. Sed fringilla porta ligula.</p>
+
<p>Attaching nuclease proteins to zinc fingers opened up possibilities for future research in gene therapy by allowing researchers to directly modify the genome though nuclease cutting.</p>
</li>
</li>
-
<li id="#1971">
+
<li id="#2000">
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/5.png" width="256" height="256" />
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/5.png" width="256" height="256" />
-
<h1>1971</h1>
+
<h1>Sangamo enters the public sector</h1>
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<p>Donec semper quam scelerisque tortor dictum gravida. In hac habitasse platea dictumst. Nam pulvinar, odio sed rhoncus suscipit, sem diam ultrices mauris, eu consequat purus metus eu velit. Proin metus odio, aliquam eget molestie nec, gravida ut sapien. Phasellus quis est sed turpis sollicitudin venenatis sed eu odio. Praesent eget neque eu eros interdum malesuada non vel leo. Sed fringilla porta ligula.</p>
+
<p></p>
</li>
</li>
-
<li id="#1977">
+
<li id="#2004">
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/6.png" width="256" height="256" />
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/6.png" width="256" height="256" />
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<h1>1977</h1>
+
<h1>Sangamo patents the zinc finger nuclease complex "Nucleic acid binding proteins (zinc finger proteins design rules)"</h1>
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<p>Donec semper quam scelerisque tortor dictum gravida. In hac habitasse platea dictumst. Nam pulvinar, odio sed rhoncus suscipit, sem diam ultrices mauris, eu consequat purus metus eu velit. Proin metus odio, aliquam eget molestie nec, gravida ut sapien. Phasellus quis est sed turpis sollicitudin venenatis sed eu odio. Praesent eget neque eu eros interdum malesuada non vel leo. Sed fringilla porta ligula.</p>
+
<p>Any use or production of zinc fingers with attached nucleases is the intellectual property of Sangamo.</p>
</li>
</li>
-
<li id="#1989">
+
<li id="#2008">
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/7.png" width="256" height="256" />
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/7.png" width="256" height="256" />
-
<h1>1989</h1>
+
<h1>Rapid open source production of zinc finger nucleases becomes available</h1>
-
<p>Donec semper quam scelerisque tortor dictum gravida. In hac habitasse platea dictumst. Nam pulvinar, odio sed rhoncus suscipit, sem diam ultrices mauris, eu consequat purus metus eu velit. Proin metus odio, aliquam eget molestie nec, gravida ut sapien. Phasellus quis est sed turpis sollicitudin venenatis sed eu odio. Praesent eget neque eu eros interdum malesuada non vel leo. Sed fringilla porta ligula.</p>
+
<p>Researcher Keith Joung of Harvard University and Mass. General Hospital develops a method for making zinc finger nuclease proteins that bind to custom target sequences.</p>
</li>
</li>
-
<li id="#1999">
+
<li id="#2009">
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/8.png" width="256" height="256" />
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/8.png" width="256" height="256" />
-
<h1>1999</h1>
+
<h1>Sangamo and Sigma-Aldrich announce licensing deal for sale of zinc finger nulease proteins.</h1>
-
<p>Donec semper quam scelerisque tortor dictum gravida. In hac habitasse platea dictumst. Nam pulvinar, odio sed rhoncus suscipit, sem diam ultrices mauris, eu consequat purus metus eu velit. Proin metus odio, aliquam eget molestie nec, gravida ut sapien. Phasellus quis est sed turpis sollicitudin venenatis sed eu odio. Praesent eget neque eu eros interdum malesuada non vel leo. Sed fringilla porta ligula.</p>
+
<p>The license allows Sigma-Aldrich to sell custom zinc finger nuclease protein pairs for approximately $30,000 each.</p>
</li>
</li>
-
<li id="#2001">
+
<li id="#2011">
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/9.png" width="256" height="256" />
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/9.png" width="256" height="256" />
-
<h1>2001</h1>
+
<h1>Context-dependency improves open-source zinc finger engineering</h1>
-
<p>Donec semper quam scelerisque tortor dictum gravida. In hac habitasse platea dictumst. Nam pulvinar, odio sed rhoncus suscipit, sem diam ultrices mauris, eu consequat purus metus eu velit. Proin metus odio, aliquam eget molestie nec, gravida ut sapien. Phasellus quis est sed turpis sollicitudin venenatis sed eu odio. Praesent eget neque eu eros interdum malesuada non vel leo. Sed fringilla porta ligula.</p>
+
<p>Keith Joung publishes tables of zinc finger binding sites that account for context-dependent effects and can be rearranged to form custom zinc finger proteins that bind to a variety of DNA sequences.</p>
</li>
</li>
-
<li id="#2011">
+
<li id="#Summer 2011">
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/10.png" width="256" height="256" />
<img src="http://people.fas.harvard.edu/~jwchew/iGEM/images/10.png" width="256" height="256" />
-
<h1>2011</h1>
+
<h1>Harvard iGEM uses novel integration of existing technologies for rapid, massive production of custom zinc fingers</h1>
-
<p>Donec semper quam scelerisque tortor dictum gravida. In hac habitasse platea dictumst. Nam pulvinar, odio sed rhoncus suscipit, sem diam ultrices mauris, eu consequat purus metus eu velit. Proin metus odio, aliquam eget molestie nec, gravida ut sapien. Phasellus quis est sed turpis sollicitudin venenatis sed eu odio. Praesent eget neque eu eros interdum malesuada non vel leo. Sed fringilla porta ligula.</p>
+
<p>We have developed a rapid, comparatively low-cost, <em>open source</em> method for making thousands of custom zinc fingers by integrating MAGE, lambda red, and chip-based synthesis technologies.</p>
</li>
</li>

Revision as of 22:22, 28 October 2011

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IP and Open Source Technology | Letter to Representatives

Zinc Finger Historical Timeline

  • Discovery of the zinc finger protein

    Sir Aaron Klug first identifies the repeated binding motif in Transcription Factor IIIA and is the first to use the term ‘zinc finger’.

  • First crystal structure of a zinc finger

    Carl Pabo and Nikola Pavletich of Johns Hopkins University solve the crystal structure of zif268, now the most-commonly studied zinc finger.

  • CEO Edward Lanphier founds Sangamo Biosciences

    Edward Lanphier leaves Somatix Therapy Corporation and makes a deal for exclusive rights to the work of Srinivan Chandrasegaran of Johns Hopkins University who combined the Fok I nuclease with zinc fingers.

  • Srinivasan Chandrasegaran publishes research on fusing Fok I nuclease to zinc finger proteins

    Attaching nuclease proteins to zinc fingers opened up possibilities for future research in gene therapy by allowing researchers to directly modify the genome though nuclease cutting.

  • Sangamo enters the public sector

  • Sangamo patents the zinc finger nuclease complex "Nucleic acid binding proteins (zinc finger proteins design rules)"

    Any use or production of zinc fingers with attached nucleases is the intellectual property of Sangamo.

  • Rapid open source production of zinc finger nucleases becomes available

    Researcher Keith Joung of Harvard University and Mass. General Hospital develops a method for making zinc finger nuclease proteins that bind to custom target sequences.

  • Sangamo and Sigma-Aldrich announce licensing deal for sale of zinc finger nulease proteins.

    The license allows Sigma-Aldrich to sell custom zinc finger nuclease protein pairs for approximately $30,000 each.

  • Context-dependency improves open-source zinc finger engineering

    Keith Joung publishes tables of zinc finger binding sites that account for context-dependent effects and can be rearranged to form custom zinc finger proteins that bind to a variety of DNA sequences.

  • Harvard iGEM uses novel integration of existing technologies for rapid, massive production of custom zinc fingers

    We have developed a rapid, comparatively low-cost, open source method for making thousands of custom zinc fingers by integrating MAGE, lambda red, and chip-based synthesis technologies.

Retrieved from "http://2011.igem.org/Team:Harvard/Human_Practices/Timeline"