Team:Wageningen UR/Project/ModelingProj1
From 2011.igem.org
(→Modeling synchronized oscillations) |
(→Modeling synchronized oscillations) |
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- | === 2. Mathematical model of the construct === | + | === 2. Mathematical model of the Hasty construct === |
Since our bio bricked oscillatory system is based on the design seen above, our first model of the system is a reproduction of the mathematical model in the [http://www.nature.com/nature/journal/v463/n7279/suppinfo/nature08753.html supplementary information] accompanying the publication mentioned. In their simulations, Danino et al. used the following set of delay differential equations, which we also used for our modeling tool written in matlab. }} | Since our bio bricked oscillatory system is based on the design seen above, our first model of the system is a reproduction of the mathematical model in the [http://www.nature.com/nature/journal/v463/n7279/suppinfo/nature08753.html supplementary information] accompanying the publication mentioned. In their simulations, Danino et al. used the following set of delay differential equations, which we also used for our modeling tool written in matlab. }} | ||
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=== 3. Conclusions for our system === | === 3. Conclusions for our system === | ||
- | The first observation from the model was that, for oscillations to occur, the flow rates may not be too fast, especially at lower cell densities. Since the device used for our system has larger dimensions than the microfluidic device used by Danino et al. the flow rates in the velocities required | + | The first observation from the model was that, for oscillations to occur, the flow rates may not be too fast, especially at lower cell densities. Since the device used for our system has larger dimensions than the microfluidic device used by Danino et al. the flow rates in the velocities required could not be achieved by varying height differences alone. Further information can be found in the information about the [[Team:Wageningen_UR/Project/Devices| devices.]] |
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+ | === 4. Expansion of the model for the double tunable oscillatory construct === | ||
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+ | The idea of the double tunable oscillatory system is that the start of the oscillations is externally inducable. | ||
Revision as of 19:00, 18 September 2011