Team:Wageningen UR/Project/ModelingProj1
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=== Expansion of the model for the double tunable oscillatory construct === | === Expansion of the model for the double tunable oscillatory construct === | ||
- | + | To model the [[Team:Wageningen_UR/Project/CompleteProject1Description#Designs| double tunable oscillator]], the original set of delay differential equations was expanded. This involved adding the effect of the repressor and activator in the form of a Hill function to the differential equations for LuxI and AiiA. The equations for the internal and external AHL concentrations were not changed. The new set of equations is seen below. | |
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'''Top: ''Adjusted set of differential equations for the double tunable oscillator'' | '''Top: ''Adjusted set of differential equations for the double tunable oscillator'' | ||
- | Since the lacI repressed hybrid promoter used for this system was designed by the [http://parts.mit.edu/igem07/index.php/Tokyo/Works Tokyo iGEM 2007] team, the equations were derived according to their model. The | + | Since the lacI repressed hybrid promoter used for this system was designed by the [http://parts.mit.edu/igem07/index.php/Tokyo/Works Tokyo iGEM 2007] team, the equations were derived according to their model. The tetR repressor was then modeled using the same template. |
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+ | This set of equations was then used to write a new matlab modeling tool, of which the GUI is depicted below. | ||
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+ | [[File:GUI_2_synchroscillator_WUR.png|center]] | ||
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+ | As can be seen in the GUI, the new variables which can be changed are now the both activators IPTG and aTc. The parameters used are still in arbitrary units and the values not yet verified with wet lab experiments. However, some | ||
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[[Team:Wageningen_UR/Project/ModelingProj1#Modeling_synchronized_oscillations| back to top]] | [[Team:Wageningen_UR/Project/ModelingProj1#Modeling_synchronized_oscillations| back to top]] | ||
}} | }} |
Revision as of 15:48, 21 September 2011