Team:Wageningen UR/Project/Applications
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(→Synchroscillator: Possible Applications) |
(→Synchroscillator: Possible Applications) |
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As there are some genes that cannot be knocked out, because without it the organism cannot survive, the use of knock-outs is limited. The oscillating system can get the expression level of a crucial gene E very low at certain time points while it makes up for the loss at other time points where it is over-expressed. This means that, by looking at changing expression patterns of other genes over time, it is possible to get interactional information for gene E that until now was very hard to study. | As there are some genes that cannot be knocked out, because without it the organism cannot survive, the use of knock-outs is limited. The oscillating system can get the expression level of a crucial gene E very low at certain time points while it makes up for the loss at other time points where it is over-expressed. This means that, by looking at changing expression patterns of other genes over time, it is possible to get interactional information for gene E that until now was very hard to study. | ||
- | Next to that, using the oscillating system, it would be possible to look at rates of interaction between genes. Imagine that gene B is regulated by gene A, which is oscillating. If the interaction speed between A & B would be extremely fast, it might be possible that gene B starts oscillating together with gene A. There should be a delay however. By looking at this delay and the resulting pattern of gene B, conclusions can be drawn about the rate of interaction between both genes. | + | Next to that, using the oscillating system, it would be possible to look at rates of interaction between genes. Imagine that gene B is regulated by gene A, which is oscillating. If the interaction speed between A & B would be extremely fast, it might be possible that gene B starts oscillating together with gene A. There should be a delay however. By looking at this delay and the resulting pattern of gene B, conclusions can be drawn about the rate of interaction between both genes. The following figure illustrates what it could look like: |
[[File:Oscillating_AB3.jpg|450px|center|thumb]] | [[File:Oscillating_AB3.jpg|450px|center|thumb]] |
Revision as of 02:15, 22 September 2011