Team:UIUC-Illinois/Project

From 2011.igem.org

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Our project is being deemed the ‘bacterial filing cabinet’.  The idea is to introduce two constructs that express distinct phenotypes into the chromosome of E. coli.  The single copy nature of these insertions will prevent either phenotype from being easily detectable.  A phenotype will be pulled out of its dormant single copy state by excision of the construct and replication into a high copy number vector.  Phenotypes can by switched by reinserting the first construct, destroying any remaining plasmid-form construct, then excising the second construct and replicating it to a high copy number. 
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''Tell us more about your project.  Give us background.  Use this is the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
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|[[Image:UIUC-Illinois_team.png|right|frame|Your team picture]]
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      <div class="title"><center>University of Illinois - International Genetically Engineered Machine</center></div>
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!align="center"|[[Team:UIUC-Illinois|Home]]
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!align="center"|[[Team:UIUC-Illinois/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2010&team_name=UIUC-Illinois Official Team Profile]
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!align="center"|[[Team:UIUC-Illinois/Project|Project]]
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!align="center"|[[Team:UIUC-Illinois/Modeling|Modeling]]
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== '''Overall project''' ==
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Your abstract
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        <div class="title">What is eChiver?</div>
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        <div class="desc"><img src="images/t1-about.jpg" align="left" />Our project, E. chiver, drew inspiration from the commonly used CRIM system, a series of plasmids that allows the user to integrate constructs into lambdoid phage sites common to many bacterial chromosomes.  Our E. chiver system adds several elements yielding new applications.  Our team designed two E. chiver constructs utilizing Lambda and P21 machinery.  Each can in theory be used to shuttle a plasmid construct between two forms:  a single chromosomal insert and a high copy number plasmid.  In their current designs the systems must function separately, but possible routes have been identified by our team to make the co-functioning of these systems possible.  We can see elements of our project being used in drug delivery systems as a method to keep a gene of interest dormant unless in the correct condition/location, and with further exploration into the co-functioning routes it may be used to create a ‘bacterial filing cabinet’.</div>
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        <div class="title">Who We Are</div>
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== Project Details==
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          <div class="name">Amanda Chang</div>
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          <div class="p-desc">This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb.This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. </div>
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=== Part 2 ===
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        <div class="core-content-block-t2-left-title">Dynamic</div>
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        <div class="desc"><img src="images/t1-about.jpg" align="left" />This is a quick description, or will be a quick description about the future iFile Project. An ecoli cell that has an all new way of changing the way we think about the function of a cell. Imagine a cell that was fully adaptable to different conditions that would maxamize productivity if needed, but would not waste energy when a cell didn't need to. Consider it the eColi cell version 2.0. The higher the number, the better right? Well, welcome to the iFile Project.</div>
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=== The Experiments ===
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        <div class="core-content-block-t2-left-title">Efficient</div>
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        <div class="desc"><img src="images/t1-about.jpg" align="left" />This is a quick description, or will be a quick description about the future iFile Project. An ecoli cell that has an all new way of changing the way we think about the function of a cell. Imagine a cell that was fully adaptable to different conditions that would maxamize productivity if needed, but would not waste energy when a cell didn't need to. Consider it the eColi cell version 2.0. The higher the number, the better right? Well, welcome to the iFile Project.</div>
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=== Part 3 ===
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        <div class="core-content-block-t2-left-title">Multi-purpose</div>
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        <div class="desc"><img src="images/t1-about.jpg" align="left" />This is a quick description, or will be a quick description about the future iFile Project. An ecoli cell that has an all new way of changing the way we think about the function of a cell. Imagine a cell that was fully adaptable to different conditions that would maxamize productivity if needed, but would not waste energy when a cell didn't need to. Consider it the eColi cell version 2.0. The higher the number, the better right? Well, welcome to the iFile Project.</div>
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== Results ==
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Revision as of 05:57, 28 September 2011

University of Illinois iGEM Team
University of Illinois - International Genetically Engineered Machine
What is eChiver?
Our project, E. chiver, drew inspiration from the commonly used CRIM system, a series of plasmids that allows the user to integrate constructs into lambdoid phage sites common to many bacterial chromosomes. Our E. chiver system adds several elements yielding new applications. Our team designed two E. chiver constructs utilizing Lambda and P21 machinery. Each can in theory be used to shuttle a plasmid construct between two forms: a single chromosomal insert and a high copy number plasmid. In their current designs the systems must function separately, but possible routes have been identified by our team to make the co-functioning of these systems possible. We can see elements of our project being used in drug delivery systems as a method to keep a gene of interest dormant unless in the correct condition/location, and with further exploration into the co-functioning routes it may be used to create a ‘bacterial filing cabinet’.
Who We Are
Amanda Chang
This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb.This is a random blurb. This is a random blurb. This is a random blurb. This is a random blurb.
Dynamic
This is a quick description, or will be a quick description about the future iFile Project. An ecoli cell that has an all new way of changing the way we think about the function of a cell. Imagine a cell that was fully adaptable to different conditions that would maxamize productivity if needed, but would not waste energy when a cell didn't need to. Consider it the eColi cell version 2.0. The higher the number, the better right? Well, welcome to the iFile Project.
Efficient
This is a quick description, or will be a quick description about the future iFile Project. An ecoli cell that has an all new way of changing the way we think about the function of a cell. Imagine a cell that was fully adaptable to different conditions that would maxamize productivity if needed, but would not waste energy when a cell didn't need to. Consider it the eColi cell version 2.0. The higher the number, the better right? Well, welcome to the iFile Project.
Multi-purpose
This is a quick description, or will be a quick description about the future iFile Project. An ecoli cell that has an all new way of changing the way we think about the function of a cell. Imagine a cell that was fully adaptable to different conditions that would maxamize productivity if needed, but would not waste energy when a cell didn't need to. Consider it the eColi cell version 2.0. The higher the number, the better right? Well, welcome to the iFile Project.

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