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| | + | </p><h1>Welcome to the TUDelft iGEM website</h1> |
| | + | <p class="paragraph_style_1" > Our team of seven students from the TU Delft is taking the challenge to compete in iGEM – the international genetics engineered machines competition. This competition channels student’s creativity and scientific skills towards the design and construction of a micro-organism with traits useful to society. TU Delft is successfully participating since 2008, thanks to the great contribution from companies and funds supporting these students. This year we are looking to you for support in our endeavor to develop and build an excellent biological machine. |
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| | + | In a competition against 150 teams from across the world the team of TU Delft will be representing the Netherlands’ strength in Synthetic Biology. In the coming summer our team of Masters and Bachelors students in chemical and life sciences will combine their skills and knowledge with the advice of several TU Delft professors to show that the Netherlands is still on the forefront of Life Sciences. |
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| | + | <p style="padding-bottom:0pt; padding-top:0pt; " class="paragraph_style_2" ></p><h4>A student competition in the field of Synthetic Biology</h4><p></p> |
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| - | =='''Project Overview''' ==
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| - | In life one is bound to encounter problems. Nature knows this more than any other and her problem-solving ingenuity is impressive. With synthetic biology we are able to combine the best of all Nature's solutions. Designing these combinations with utility for humans in mind results in so-called “Genetically Engineered Machines”, the core of iGEM.
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| - | In our project we strive for full control of the attachment and detachment of cells. In nature attachment consists of a complex network involving an extracellular matrix containing a wide variety of compounds. This complexity has hindered easy regulation. We will give ''Escherichia coli'' a much simpler but equally effective way of binding: mussel glue. Expressing the strongest protein responsible for the attachment of mussels to rocks, we can allow ''E. coli'' to strongly attach to even glass and plastic, whenever we want it, and subsequently releasing it again. This system should be viewed in the same category as “ the wheel”, by itself it is just a neat trick, but combination is key. Combining it for example with an ''E. coli'' capable biocatalytic conversion , one can create microbial production lines, use attachment for temporary rapid settling of biomass before product removal, or achieve fundamental premiers like bacterial cells forming a micro circle on command.
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| - | ===Workflow===
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| - | Our workflow has been designed in such a way that each project is individual and independent. All the projects however contribute to one greater project.
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| - | [[File:TUDelft-Horizontal_Workflow.jpg]]
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