Team:Peking R/Biosafety

From 2011.igem.org

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   <p><span class="VISITORSFROM">VISITORS FROM......</span></p>
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   <a href="http://www2.clustrmaps.com/user/205dd217"><img src="http://www2.clustrmaps.com/stats/maps-no_clusters/2011.igem.org-Team-Peking_R-thumb.jpg" alt="Locations of visitors to this page" width="166" /></a>
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  <p><strong>Q:</strong> Would any of your project ideas raise safety issues in terms of: <br />
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    researcher safety, public safety, or  environmental safety?</p>
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  <p><strong>A:</strong> As our project aims at establishing a facile platform for soft-coding of genetic program in bacteria, it may bring about certain safety issues regarding researcher and environmental safety. Therefore, we have carefully revised experiment guidelines and safety rules to minimize possible hazards to researchers safety and environmental safety,  placing extra stress on properly handling bacteria, plasmids and  nucleotide-related reagents to prevent undesirable spread of genes into the  environment. All researchers are required to clean up their working area and  make sure no pollutants are left unattended. Besides, since we are not  conducting large-scale proliferation of microorganisms, and Protocols for preservation and operation of common E.coli strains are strictly adhered to, the possibility of threatening public safety is further reduced. </p>
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<p>&nbsp;</p>
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  <p><strong>Q:</strong> Do any of the new BioBrick parts (or devices) that you made this year raise any safety issues?</p>
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  <p>If yes, did you document these issues in the Registry? How did you manage to handle the safety issue? How could other  teams learn from your experience?</p>
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  <p><strong>A:</strong> Since we primarily focus on evolving existing non-biohazard parts, mainly RNA device for translation regulation, none of the new BioBrick parts we made this year would raise any safety issue according to our current profession context.</p>
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    <p><span class="biosafety"><span class="biosafety_question">1. </span></span>Would any of your project ideas raise safety issues in terms of: <br />
+
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      researcher safety, public safety, or  environmental safety?</p>
+
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    <p class="article">As our project aims at establishing a facile platform for soft-coding of genetic program in bacteria, it may bring about certain safety issues<strong class="biosafety"> regarding researcher and environmental safety</strong>. Therefore, we have carefully revised experiment guidelines and safety rules to minimize possible hazards to <strong class="biosafety">researchers safety and environmental safety</strong><strong></strong>,  placing extra stress on properly handling bacteria, plasmids and  nucleotide-related reagents to prevent undesirable spread of genes into the  environment. All researchers are required to clean up their working area and  make sure no pollutants are left unattended. Besides, since we are not  conducting large-scale proliferation of microorga</p>
+
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    <p class="article">nisms, and <strong class="biosafety">Protocols for preservation and operation</strong> of common <em>E</em>.<em>coli </em>strains<strong class="biosafety"> are strictly adhered to</strong>, the possibility of threatening public safety is further reduced. </p>
+
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    <p class="article">2. Do any of the new BioBrick parts (or devices) that you ma<img name="" src="" align="right" width="364" height="272" alt="" />de this year raise any safety issues?</p>
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    <p class="article"> If yes,  
+
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      did you document these issues in the Registry?  
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      How did you manage to handle the safety issue?     How could other  teams learn from your experience?</p>
+
-
    <p class="article">Since we primarily focus on evolving existing <strong class="biosafety">non-biohazard parts</strong>, mainly RNA device for translation regulation, <strong class="biosafety">none</strong> of the new BioBrick parts we made this year<strong class="article"> would raise any safety issue</strong> according to our current profession context.</p>
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    <p>&nbsp;</p>
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    <p class="article">3. Is there a  local biosafety group, committee, or review board at your institution? <br />
+
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      If yes, what  does your local biosafety group think about your project? <br />
+
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      If no, which  specific biosafety rules or guidelines do you have to consider in your country? </p>
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    <p class="article"><strong class="biosafety">Yes</strong>. Both<strong class="article"> our institution</strong> and <strong class="biosafety">the state government</strong> have committees  that establish guidelines and policies on biosafety.<strong class="biosafety"> Evaluation of biosafety in research laboratories</strong> are regularly  carried out, including evaluation of<strong class="biosafety"> research proposals</strong> that may determine whether grants are given, as well as <strong class="biosafety">monitoring of experimental procedures</strong> in the laboratories to ensure that they meet the standards of biosafety.</p>
+
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    <p class="article">To learn more about PR China’s administrations and  regulations concerning biosafety. please<strong class="biosafety"> click the following links</strong>:</p>
+
-
    <ul>
+
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      <li class="article"><a href="http://english.biosafety.gov.cn/" target="_blank">National Biosafety Office</a>,  Ministry of Environmental Protection, PR China</li>
+
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    </ul>
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    <p align="left" class="article">This website lists policies, regulations and  contracts on ensuring safe research in biology and publishes latest domestic  and international news on bio</p>
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    <p align="left" class="article">safety.</p>
+
-
    <ul>
+
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      <li class="article"><a href="http://www1.www.gov.cn/zwgk/2005-05/23/content_256.htm" target="_blank">Biosafety regulation on  pathogenic microbes</a>, PR China</li>
+
-
    </ul>
+
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    <p class="article">This webpage  declares rules and policies established by the State Department that regulates  laboratory management regarding pathogenic microbes, including classification  of pathogenic microbes, respective treatments and control of laboratory infection.</p>
+
-
    <p class="article">&nbsp;</p>
+
-
    4. Do you have any other ideas how to deal  with safety issues that could be useful for future iGEM competitions? How could  parts, devices and systems be made even safer through biosafety engineering?
+
-
  <p>Enhancement of  biosafety in the iGEM competitions requires the collaboration of every team as  well as the iGEM committee. Since BioBrick provides standard synthetic biology  parts, it would be relatively easier to <strong class="biosafety">establish  safety standards </strong>for handling these parts. <strong class="biosafety">Special lectures</strong> on how measures could also be taken to minimize  safety issues raised by experiments in synthetic biology may be given during  the iGEM workshops. <br />
+
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    As for  laboratory research, besides a reference sequence databank that may be referred  to for possibly hazardous genes, <strong class="biosafety">self-destruction  functions of plasmids</strong> in response to undesirable hosts are also  recommendable for BioBrick parts. <strong class="biosafety">Orthogonality  in the design and construction of functional genetic devices</strong> may also be  encouraged in the competition in order to reduce the probability of horizontal  gene transfer that may endow wild-type species with overly high advantages in  intraspecies competition or even underestimated virulence.</p>
+
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  <p>&nbsp;</p>
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   <p>&nbsp;</p>
   <p>&nbsp;</p>
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   </div></td>
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   <p><strong>Q: </strong> Is there a local biosafety group,  committee, or review board at your institution? <br />
-
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+
    If yes, what does your local biosafety  group think about your project? <br />
-
   <td colspan="3" bgcolor="#FFFF99">&nbsp;</td>
+
    If no, which specific biosafety rules or  guidelines do you have to consider in your country? </p>
-
   <td rowspan="29" bgcolor="#FFFFFF">&nbsp;</td>
+
   <p><strong>A:</strong> Yes. Both our institution and the state  government have committees that establish guidelines and policies on biosafety.  Evaluation of biosafety in research laboratories are regularly carried out,  including evaluation of research proposals that may determine whether grants  are given, as well as monitoring of experimental procedures in the laboratories  to ensure that they meet the standards of biosafety.</p>
-
  <td></td>
+
   <p>To learn more about PR China's  administrations and regulations concerning biosafety. please click the  following links:</p>
-
</tr>
+
   <p>National Biosafety Office, Ministry of  Environmental Protection, PR China</p>
-
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+
  <p>This website lists policies, regulations  and contracts on ensuring safe research in biology and publishes latest  domestic and international news on biosafety.</p>
-
  <td rowspan="28" bgcolor="#FFFF99">&nbsp;</td>
+
<p>Biosafety regulation on pathogenic  microbes, PR China</p>
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<p>&nbsp; </p>
 +
<p><strong>Q: </strong> Do you have any other ideas how to deal  with safety issues that could be useful for future iGEM competitions? How could  parts, devices and systems be made even safer through biosafety engineering?  Enhancement of biosafety in the iGEM competitions requires the collaboration of  every team as well as the iGEM committee. Since BioBrick provides standard  synthetic biology parts, it would be relatively easier to establish safety  standards for handling these parts. Special lectures on how measures could also  be taken to minimize safety issues raised by experiments in synthetic biology  may be given during the iGEM workshops. </p>
 +
  <p> <strong>A:</strong> As for laboratory research, besides a  reference sequence databank that may be referred to for possibly hazardous  genes, self-destruction functions of plasmids in response to undesirable hosts  are also recommendable for BioBrick parts. Orthogonality in the design and  construction of functional genetic devices may also be encouraged in the  competition in order to reduce the probability of horizontal gene transfer that  may endow wild-type species with overly high advantages in intraspecies  competition or even underestimated virulence.</p>
 +
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Q: Would any of your project ideas raise safety issues in terms of:
researcher safety, public safety, or environmental safety?

A: As our project aims at establishing a facile platform for soft-coding of genetic program in bacteria, it may bring about certain safety issues regarding researcher and environmental safety. Therefore, we have carefully revised experiment guidelines and safety rules to minimize possible hazards to researchers safety and environmental safety, placing extra stress on properly handling bacteria, plasmids and nucleotide-related reagents to prevent undesirable spread of genes into the environment. All researchers are required to clean up their working area and make sure no pollutants are left unattended. Besides, since we are not conducting large-scale proliferation of microorganisms, and Protocols for preservation and operation of common E.coli strains are strictly adhered to, the possibility of threatening public safety is further reduced.

 

Q: Do any of the new BioBrick parts (or devices) that you made this year raise any safety issues?

If yes, did you document these issues in the Registry? How did you manage to handle the safety issue? How could other teams learn from your experience?

A: Since we primarily focus on evolving existing non-biohazard parts, mainly RNA device for translation regulation, none of the new BioBrick parts we made this year would raise any safety issue according to our current profession context.

 

Q: Is there a local biosafety group, committee, or review board at your institution?
If yes, what does your local biosafety group think about your project?
If no, which specific biosafety rules or guidelines do you have to consider in your country?

A: Yes. Both our institution and the state government have committees that establish guidelines and policies on biosafety. Evaluation of biosafety in research laboratories are regularly carried out, including evaluation of research proposals that may determine whether grants are given, as well as monitoring of experimental procedures in the laboratories to ensure that they meet the standards of biosafety.

To learn more about PR China's administrations and regulations concerning biosafety. please click the following links:

National Biosafety Office, Ministry of Environmental Protection, PR China

This website lists policies, regulations and contracts on ensuring safe research in biology and publishes latest domestic and international news on biosafety.

Biosafety regulation on pathogenic microbes, PR China

This webpage declares rules and policies established by the State Department that regulates laboratory management regarding pathogenic microbes, including classification of pathogenic microbes, respective treatments and control of laboratory infection.

 

Q: Do you have any other ideas how to deal with safety issues that could be useful for future iGEM competitions? How could parts, devices and systems be made even safer through biosafety engineering? Enhancement of biosafety in the iGEM competitions requires the collaboration of every team as well as the iGEM committee. Since BioBrick provides standard synthetic biology parts, it would be relatively easier to establish safety standards for handling these parts. Special lectures on how measures could also be taken to minimize safety issues raised by experiments in synthetic biology may be given during the iGEM workshops.

A: As for laboratory research, besides a reference sequence databank that may be referred to for possibly hazardous genes, self-destruction functions of plasmids in response to undesirable hosts are also recommendable for BioBrick parts. Orthogonality in the design and construction of functional genetic devices may also be encouraged in the competition in order to reduce the probability of horizontal gene transfer that may endow wild-type species with overly high advantages in intraspecies competition or even underestimated virulence.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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