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China's wine culture has developed for thousands of years,and the wine as a traditional drink is closely
linked with people's life. But excessive drinking will bring a lot of inconvenience, causing many social
problems. For example, in recent years, drunk driving has become a ferocioustraffic killer.Therefore,we hope to
develop a kind of engineering bacteria, which can reproduct in the human body , and has the ability of
decomposition of excess alcohol function.
As the host bacteria of exogenous gene expression,lactobacillus' superiority is mainly manifested in the
following:1.lactobacillus can colonize in the respiratory system, digestive system and urinary system, playing
an important role in maintain ecological balance; 2.lactobacillus has confirmed that has no pathogenicity in
food industry's various fields of long-term application, is recognized as the security level (GRAS, generally
recognized as safe) microorganisms.As a result , we choose the lactic acid bacteria as recipients in gene
engineering.
In the human body 's metabolism process, the alcohol is mainly catalyzed into acetaldehyde acetaldehyde by
alcohol dehydrogenase ( ADH) in liver, further by acetaldehyde dehydrogenase (ALDH ) catalytic transformation
into acetic acid.We found two genes expressing of ADH and ALDH, ADH1B2 and ALDH2, hoping to put them into
BioBrick, introducing into Lactobacillus expression. At the same time we will introduce promoter of lactate
detection as well as self-cracking mechanism, improving the gene pathway.
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