"

From 2011.igem.org

• Our design
  

To achieve this goal, we use a species of magnetic bacteria, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we choose three genes to achieve symbiosis within glial cell: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitated escape from phagosomes.

• Our design is made up of the following two devices:
  

• Optomagnetic Design
  • Bridge magnetics and optogenetics
• Immunological Solution
  • Make magnetic bacteria symbiosis with glia cell

• Achievements

• 1.We designed a new cloning vector of AMB-1 which is compatible with common biobricks, make it easier for igemers to clone magnetic bacteria AMB-1.
• 2.We submitted over 60 parts to the resgristry, which can be used for application magnetic enlightment, cloning AMB-1, Symbiosis with Human cell.
• 3.We designed helical anti-membrane protein CHAMP for mms13, seperate two helix of magnetite binding protein mms13. Make it a flexible use of magnetic field in iGEM.
• 4.We removed a PstI site of the part BBa_K299806, which express MinC protein. Improve the compacity of this part.
• 5.We designed a free online software, which provides an automated ONE-STEP primer design service of BioBricks for iGEM.
• Our institute
• The official web pages of our school - National Yang Ming University (NYMU):
  • [http://web.ym.edu.tw/front/bin/home.phtml in Chinese]
  • [http://nymu-e.web.ym.edu.tw/front/bin/home.phtml in English]
• Follow the two links below to see The Beauty of NYMU
  • [http://issue.ym.edu.tw/cia/new/ Take a panoramic scenery view of our university]
  • [http://issue.ym.edu.tw/cia/new/tw/ym720.html Take a tour of our university]