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Team:MIT/Tools/
From 2011.igem.org
''mcell'' - A Multicellular Modeling Framework
''mcell'' is a small set of Python classes that allows the enterprising modeler to: * Easily create very flexible models of of multicellular dynamics * Manage the models already created through a simple command-line interface * Easily change defined parameters in models * Render the runs of the models in a convenient, simple way * Analyze the runs of the models through histograms and clustering ''mcell'' is a thin layer on top of the combination of [BionetSolver], which model internal cell states as systems of ODEs, and [CompuCell3D], which models cell shape dynamics using the Glazier-Graner-Hogeweg methos. It was created largely in reaction to inconveniences experienced when using BionetSolver and CompuCell3D as detailed [here]. It is in continuous development.Quick Links
Why?
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Installation
How it works
In mcell models, BionetSolver models the internal cell states, and CompuCell3D models the cell dynamics.BionetSolver
BionetSolver reads one or several [SBML] files, each of which define a ''circuit'' as a system of chemical reactions in several containers with given rate laws. SBML models are simply XML files, and can be written with a text editor; however, it is much easier to define them using a graphical designer, like [JDesigner], or using a simple scripting language, like [Jarnac]. (Both of those editors can be obtained by installing the [Synthetic Biology Workbench]. After loading the circuits, BionetSolver is in posession of a system of ODEs that define the internal state of each modeled cell. To simulate each cell, BionetSolver simply Euler-steps its ODE system forward with a fixed time step. Some of the variables in the ODE model (like, say, the concentration of a protein on the neighboring cells) are actually parameters that are continually updated from the CompuCell3D thread.CompuCell3D
Model Management
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Rendering and Analysis
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