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Team:NYC Wetware
From 2011.igem.org
Our Team
Our iGEM squadron consists of students from the Dalton School, Hunter College, Columbia University, Yeshiva University, NYU-Poly, and Cornell University. Our advisors (and donated workspace) reside at Weill Cornell Medical College on the Upper East Side of Manhattan. Briefly, over the summer we will be investigating the genetic mechanisms for ionizing radiation resistance in Deinococcus radiodurans through genome sequencing, RNA-sequencing experiments, and high throughput cloning.
Our Project
We're placing genes from Deinococcus radiodurans into E. coli and upregulating some of E. coli's own genes. We targeted genes associated with radioresistance in the hopes of conferring radioresistance upon radiovulnerable E. coli. Future applications for the control of cellular resistance to radiation include bioremediation of radioactive waste, highly effective stem cell transplants, and terraforming Mars.
Our Approach
We've been following the literature on two approaches to describing the particulars of D. rad's radioresisitance:
1. DNA Repair - Dr John Battista's work has focused on the rapid DNA repair mechanisms of D. rad and their attendant proteins as the responsible parties for it extraordinary radioresistance.
2. Iron-Manganaese Ratios - Dr Michael Daly's research suggests that D. rad uses manganese as an antioxidant to fight radiation damage.
Yeshiva University Wetlab Team Members
Jake Friedman
David Sweet
Yossi Steinberger
Yair Saperstein
Weill Cornell Medical Grad Students + Faculty Advisors
Russell Durrett, Christopher Mason PhD - Institute for Computational Biology
Alex Hansler, Steven Gross PhD - Department of Pharmacology
Sponsors
- Illumina
- Agilent
- Science House
- Quartzy
- NY SynBio
- Integrated DNA Technologies
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