Team:Wageningen UR/Project/CompleteProject2Description

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Project Description
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Fungal Track 'n Trace: project description

The aim of this project is to design and implement a sustained, self-propagating intercellular signalling system in the hyphal fungus Aspergillus nidulans. After initial induction, a genetic feed-forward loop will activate, resulting in the production of a signalling molecule. This molecule will diffuse through the septum into neighbouring cells, where it will enter the nuclei, and activate a transcription factor. This transcription factor will in turn activate the feed-forward loop, increasing the production of the signalling molecule and thereby allowing the signal to propagate throughout the hyphal network. This process will be visualized using fluorescent reporter proteins.

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