"
Team:TU-Delft/Project
From 2011.igem.org
iGEM 2011
| You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing. | |
|
Tell us more about your project. Give us background. Use this is the abstract of your project. Be descriptive but concise (1-2 paragraphs) | |
| Team Example |
| Home | Team | Official Team Profile | Project | Parts Submitted to the Registry | Modeling | Notebook | Safety | Attributions |
|---|
Overall project
In life one is bound to encounter problems. Nature knows this more than any other and her problem-solving ingenuity is impressive. With synthetic biology we are able to combine the best of all Nature's solutions. Designing these combinations with utility for humans in mind results in so-called “Genetically Engineered Machines”, the core of iGEM.
In our project we strive for full control of the attachment and detachment of cells. In nature attachment consists of a complex network involving an extracellular matrix containing a wide variety of compounds. This complexity has hindered easy regulation. We will give Escherichia coli a much simpler but equally effective way of binding: mussel glue. Expressing the strongest protein responsible for the attachment of mussels to rocks, we can allow E coli to strongly attach to even glass and plastic, whenever we want it, and subsequently releasing it again. This system should be viewed in the same category as “ the wheel”, by itself it is just a neat trick, but combination is key. Combining it for example with an E coli capable biocatalytic conversion , one can create microbial production lines, use attachment for temporary rapid settling of biomass before product removal, or achieve fundamental premiers like bacterial cells forming a micro circle on command.
Project Details
Part 2
The Experiments
Part 3
Results
