Team:Peking S/team/links

Year 2010
Biocontamination Kit  We’ve developed a strategy for heavy metal bioreporter and bioabsorbent engineering, based on reverse engineering principle, which will help us to break the limitation of our current knowledge and research method. As MerR family TFs share highly conserved homology and most kinds of heavy metals have corresponding MerR family TFs(Brown et al., 2003; Hobman, 2007; Hobman et al., 2005; Julian et al., 2009), we can state that we have developed an extensible method to construct heavy metal decontamination kits composed of valid bioreporters and bioabsorbents for field application in the near future.

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Year 2009
Conditioned Reflex Mimicking in E.coli We are engineering our E.coli cells to process the correlation information of two environmental signal, similar to the process of classical conditioning in higher organisms. In our circuits we use a bistable switch as the memory module to represent the memory state; we also constructed a series of AND gates which can sense conditioned and unconditioned signals, and output a repressor protein to change the memory state of the bistable switch. In this way, our E.coli cells can convert the information on the concurrence of two signals to its memory. After the memory module is switched, given the conditioned stimulus, E.coli will activate its reporter module and thus exhibit the "conditioned response". more detail Year 2008