Methods: Approaching Our Project
As C. elegans is a multi-celleular organism, developing a concrete approach to our project required extensive research and planning. This section outlines our general methodology to tackling the bioremediation concept.
The Nose
After narrowing down our project idea, the first step we took was to research compounds and G-protein coupled receptors (GPCRs) our worm could use to detect pollutants.
The Nerves
After narrowing down our project idea, the first step we took was to research compounds and G-protein coupled receptors (GPCRs) our worm could use to detect pollutants.
References
1. PharmacoInformatics Laboratory, GLIDA: GPCR Ligand Database (ver. 2.04, 2010), Kyoto University
2. Kiyohara H, Torigoe S, Kaida N, Asaki T, Iida, T, Hayashi H and Takizawa N. (1994) Cloning and Characterization of a Chromosomal Gene Cluster, pah, That Encodes the Upper Pathway for Phenanthrene and Naphthalene Utilization by Pseudomonas putida OUS82. Journal of Bacteriology, 176:2439-2443.
3. Ahmed S and Hodgkin J. (2000) MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans. Nature, 403(6766):149-151.
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